Leonardi A, Arata L, Farinelli M, Cocito L, Schenone A, Tabaton M, Mancardi G L
Department of Clinical Neurology, University of Genoa, Italy.
J Neurol Sci. 1987 Dec;82(1-3):281-90. doi: 10.1016/0022-510x(87)90024-4.
Cerebrospinal fluid (CSF) was studied in 2 cases of Devic's syndrome (DS). In one of these cases autopsy was carried out. The main CSF feature in DS is the association of blood-brain barrier damage and intrathecal IgG synthesis. These findings are in keeping with our neuropathological observation of diffuse central nervous system vasculitis and leptomeningitis. As a whole, our CSF and neuropathological findings in DS are consistently different from those in multiple sclerosis.
