Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA.
Urology. 2013 Oct;82(4):881-6. doi: 10.1016/j.urology.2013.05.034. Epub 2013 Jul 31.
To examine the associations between fasting serum glucose, insulin concentrations, and insulin resistance and benign prostatic hyperplasia (BPH) in a population-based cohort of African American men.
Using the Flint Men's Health Study (FMHS), we examined how fasting serum glucose and insulin concentrations and calculated Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR) related to burden and progression of clinical markers of BPH in African American men aged 40-79 years.
Among 369 men at baseline, mean age was 56.6 years and approximately 70% were overweight/obese (body mass index [BMI] ≥25 kg/m(2)). One hundred forty-eight men (34.4%) reported moderate to severe lower urinary tract symptoms (LUTS) (American Urological Association Symptom Index [AUASI] ≥8). There were no significant trends of metabolic disturbances as measured by serum glucose, insulin, or HOMA-IR in men with indications of BPH compared to those without.
In this population-based study of African American men aged 40-79 years, we did not observe any significant associations between hyperglycemia, hyperinsulinemia, and insulin resistance and burden and progression of BPH after adjustment for age and BMI. This may be due, in part, to the single measurement of glucose and insulin, which may not adequately reflect average glucose metabolism. Further studies examining measures of long-term glycemic control and BPH in racially diverse populations are warranted.
在一项基于人群的非裔美国男性队列中，研究空腹血糖、胰岛素浓度和胰岛素抵抗与良性前列腺增生（BPH）之间的关系。
利用弗林特男性健康研究（FMHS），我们研究了空腹血清葡萄糖和胰岛素浓度以及计算的胰岛素抵抗评估模型（HOMA-IR）与 40-79 岁非裔美国男性的 BPH 临床标志物的负担和进展之间的关系。
在 369 名基线男性中，平均年龄为 56.6 岁，约 70%超重/肥胖（体重指数 [BMI] ≥25 kg/m²）。148 名男性（34.4%）报告有中度至重度下尿路症状（LUTS）（美国泌尿外科学会症状指数 [AUASI] ≥8）。与没有 BPH 迹象的男性相比，BPH 迹象的男性的血清葡萄糖、胰岛素或 HOMA-IR 等代谢紊乱指标没有明显的趋势。
在这项针对 40-79 岁非裔美国男性的基于人群的研究中，我们没有观察到高血糖、高胰岛素血症和胰岛素抵抗与 BPH 的负担和进展之间存在任何显著关联，调整年龄和 BMI 后也是如此。这可能部分归因于葡萄糖和胰岛素的单次测量，这可能无法充分反映平均血糖代谢。进一步研究需要在种族多样化的人群中检查长期血糖控制和 BPH 的指标。
