Division of Urology, University of California San Diego, San Diego, CA, USA.
Eur Urol. 2011 Dec;60(6):1173-80. doi: 10.1016/j.eururo.2011.07.040. Epub 2011 Jul 23.
Two potential targets for preventing chronic lower urinary tract symptoms (LUTS) in older men are obesity and physical activity.
To examine associations of adiposity and physical activity with incident LUTS in community-dwelling older men.
DESIGN, SETTING, AND PARTICIPANTS: The Osteoporotic Fractures in Men Study (MrOS) is a prospective cohort of men ≥65 yr of age. MrOS participants without LUTS and a history of LUTS treatment at baseline were included in this analysis.
Adiposity was measured with body mass index (BMI), physical activity with the Physical Activity Scale for the Elderly (PASE) and self-report of daily walking, and LUTS with the American Urological Association Symptom Index.
The mean age (standard deviation [SD]) of the 1695 participants was 72 (5) yr at baseline. At a mean (SD) follow-up of 4.6 (0.5) yr, 524 (31%) of men reported incident LUTS. In multivariate analyses, compared with men of normal weight at baseline (BMI <25 kg/m²), overweight (BMI: 25.0-29.9 kg/m²) and obese (≥30 kg/m²) men were 29% (adjusted odds ratio [OR(adj)]: 1.29; 95% confidence interval [CI], 1.00-1.68) and 41% (OR(adj): 1.41; 95% CI, 1.03-1.93) more likely to develop LUTS, respectively. Men in the highest quartile of physical activity were 29% (OR(adj): 0.71; 95% CI, 0.53-0.97) and those who walked daily 20% (OR(adj): 0.80; 95% CI, 0.65-0.98) less likely than their sedentary peers to develop LUTS, adjusting for BMI. The homogeneous composition of MrOS potentially diminishes the external validity of these results.
In older men, obesity and higher physical activity are associated with increased and decreased risks of incident LUTS, respectively. Prevention of chronic urinary symptoms represents another potential health benefit of exercise in elderly men.
预防老年男性慢性下尿路症状（LUTS）的两个潜在目标是肥胖和身体活动。
研究社区居住的老年男性中肥胖和身体活动与新发 LUTS 的关系。
设计、地点和参与者：男性骨质疏松症研究（MrOS）是一项≥65 岁男性的前瞻性队列研究。本分析纳入了无 LUTS 且基线时无 LUTS 治疗史的 MrOS 参与者。
肥胖用体重指数（BMI）测量，身体活动用老年人身体活动量表（PASE）和日常步行自我报告测量，LUTS 用美国泌尿协会症状指数测量。
1695 名参与者的平均（标准差[SD]）年龄为 72（5）岁。在平均（SD）随访 4.6（0.5）年后，524 名（31%）男性报告出现新发 LUTS。在多变量分析中，与基线时体重正常（BMI<25 kg/m²）的男性相比，超重（BMI：25.0-29.9 kg/m²）和肥胖（≥30 kg/m²）男性患 LUTS 的风险分别增加 29%（调整后优势比[OR（adj）]：1.29；95%置信区间[CI]：1.00-1.68）和 41%（OR（adj）：1.41；95% CI：1.03-1.93）。身体活动最高四分位的男性患 LUTS 的风险分别降低 29%（OR（adj）：0.71；95% CI：0.53-0.97）和每天行走 20%（OR（adj）：0.80；95% CI：0.65-0.98），与久坐不动的同龄人相比。MrOS 的同质组成可能降低了这些结果的外部有效性。
在老年男性中，肥胖和较高的身体活动分别与新发 LUTS 的风险增加和降低相关。预防慢性尿症状代表了老年男性运动的另一个潜在健康益处。
