University of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Biomaterials. 2013 Nov;34(33):8013-7. doi: 10.1016/j.biomaterials.2013.07.044. Epub 2013 Jul 31.
Extended life expectancy and medical development has led to an increased reliance on biomaterial implants and devices to support or restore human anatomy and function. However, the presence of an implanted biomaterial results in an increased susceptibility to infection. Due to the severity of the potential outcomes of biomaterial-associated infection, different strategies have been employed to reduce the infection risk. Interestingly, degradable biological materials demonstrate increased resistance to bacterial infection compared to non-degradable synthetic biomaterials. Current knowledge about the specific mechanisms of how degradable biological materials are afforded increased resistance to infection is limited. Therefore, in this paper a number of hypotheses to explain the decreased infection risk associated with the use of degradable versus non-degradable biomaterials are evaluated and discussed with reference to the present state of knowledge.
预期寿命的延长和医学的发展导致人们越来越依赖生物材料植入物和设备来支持或恢复人体解剖结构和功能。然而，植入生物材料会增加感染的易感性。由于生物材料相关性感染的潜在后果严重，已经采用了不同的策略来降低感染风险。有趣的是，与不可降解的合成生物材料相比，可降解生物材料显示出对细菌感染更高的抵抗力。目前对于可降解生物材料如何获得更高的抗感染能力的具体机制的了解是有限的。因此，本文评估并讨论了一些假设，以解释与使用可降解与不可降解生物材料相关的感染风险降低的原因，并参考了目前的知识状态。
