Li Huijun, Hu Cheng, Yu Huijun, Chen Chuanzhong
Shenzhen Research Institute of Shandong University Shenzhen 518057 Guangdong P. R. China
Key Laboratory of High-efficiency and Clean Mechanical Manufacture (Shandong University), Ministry of Education, School of Mechanical Engineering, Shandong University Ji'nan 250061 Shandong P. R. China.
RSC Adv. 2018 Jan 19;8(7):3736-3749. doi: 10.1039/c7ra11593h. eCollection 2018 Jan 16.
Articular cartilage (AC) defects lack the ability to self-repair due to their avascular nature and the declined mitotic ability of mature chondrocytes. To date, cartilage tissue engineering using implanted scaffolds containing cells or growth factors is the most promising defect repair method. Scaffolds for cartilage tissue engineering have been comprehensively researched. As a promising scaffold biomaterial for AC defect repair, the properties of chitosan are summarized in this review. Strategies to composite chitosan with other materials, such as polymers (including collagen, gelatin, alginate, silk fibroin, poly-caprolactone, and poly-lactic acid) and bioceramics (including calcium phosphate, calcium polyphosphate, and hydroxyapatite) are presented. Methods to manufacture three-dimensional porous structures to support cell attachment and nutriment exchange have also been included.
关节软骨（AC）缺损因其无血管特性以及成熟软骨细胞有丝分裂能力的下降而缺乏自我修复能力。迄今为止，使用含有细胞或生长因子的植入支架进行软骨组织工程是最有前景的缺损修复方法。用于软骨组织工程的支架已得到全面研究。作为一种用于AC缺损修复的有前景的支架生物材料，本文综述了壳聚糖的特性。还介绍了将壳聚糖与其他材料复合的策略，如聚合物（包括胶原蛋白、明胶、藻酸盐、丝素蛋白、聚己内酯和聚乳酸）和生物陶瓷（包括磷酸钙、聚磷酸钙和羟基磷灰石）。也包括制造三维多孔结构以支持细胞附着和营养交换的方法。
