图片排序任务表现表明双相情感障碍患者存在心理理论缺陷。
Picture sequencing task performance indicates theory of mind deficit in bipolar disorder.
机构信息
Brain and Psychological Sciences Research Centre, Faculty of Life and Social Sciences, Swinburne University of Technology, Melbourne, Australia; Monash Alfred Psychiatry research centre (MAPrc), The Alfred Hospital and Monash University Central Clinical School, 607 St Kilda Road, Melbourne, Australia.
出版信息
J Affect Disord. 2013 Dec;151(3):1132-4. doi: 10.1016/j.jad.2013.07.009. Epub 2013 Jul 31.
BACKGROUND
This paper reports the performance of DSM-IV-TR diagnosed bipolar disorder (BD) patients on a well-recognised measure of theory of mind (ToM) that commonly elicits group-related differences in schizophrenia research.
METHODS
Forty-nine BD patients and 49 age and gender matched controls completed Langdon and Coltheart (1999)Picture Sequencing Task.
RESULTS
Relative to controls, patients with BD performed significantly worse on the ToM relevant false-belief stories of the picture sequencing task, but not on the control stories requiring social script knowledge, executive control or an understanding of causal connexions. There were no differences in the ToM performance of symptomatic versus euthymic patients or those categorised as having BD I or BD II.
LIMITATIONS
As sub group sizes were small, data suggesting a trait-like deficit in ToM should be interpreted with caution.
CONCLUSIONS
The results support previous evidence of ToM impairment in BD and indicate a potential endophenotypic overlap in the phenomenology of both schizophrenia and BD.
背景
本文报告了 DSM-IV-TR 诊断为双相情感障碍（BD）的患者在一项公认的心理理论（ToM）测量上的表现，该测量常用于引发精神分裂症研究中的群体差异。
方法
49 名 BD 患者和 49 名年龄和性别匹配的对照组完成了 Langdon 和 Coltheart（1999）的图片序列任务。
结果
与对照组相比，BD 患者在图片序列任务的 ToM 相关错误信念故事上的表现明显较差，但在需要社会脚本知识、执行控制或因果关系理解的控制故事上没有差异。在有症状和缓解期的患者或被归类为 BD I 或 BD II 的患者之间，ToM 表现没有差异。
局限性
由于亚组规模较小，提示 ToM 存在特质缺陷的数据应谨慎解释。
结论
结果支持 BD 中存在 ToM 损伤的先前证据，并表明精神分裂症和 BD 的现象学之间存在潜在的表型重叠。
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