Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, PR China.
Behav Brain Res. 2013 Sep 15;253:212-6. doi: 10.1016/j.bbr.2013.07.052. Epub 2013 Aug 2.
Tetramethylpyrazine is used in the treatment of many neurological diseases because of its neuroprotective effect. Here, we demonstrate that administration of tetramethylpyrazine effectively reverses memory deficits induced by scopolamine. Moreover, tetramethylpyrazine preserves postsynaptic protein synthesis and restores cAMP/PKA/CREB pathway signaling deficits. Our study not only explores the actions of tetramethylpyrazine on synapses, but also provides novel evidence for the possible therapeutic use of tetramethylpyrazine in dementia.
四甲基吡嗪因其神经保护作用而被用于治疗多种神经疾病。在这里，我们证明了四甲基吡嗪的给药可有效逆转东莨菪碱诱导的记忆缺陷。此外，四甲基吡嗪还能维持突触后蛋白的合成，并恢复 cAMP/PKA/CREB 信号通路的缺陷。我们的研究不仅探讨了四甲基吡嗪对突触的作用，还为四甲基吡嗪在痴呆症治疗中的可能应用提供了新的证据。
