Florey Institute of Neuroscience and Mental Health, Kenneth Myer Building, University of Melbourne, Parkville, Australia.
Behav Brain Res. 2013 Sep 15;253:318-22. doi: 10.1016/j.bbr.2013.07.041. Epub 2013 Jul 31.
Huntington's disease (HD) is a neurodegenerative disorder marked by cognitive, psychiatric and motor decline, and is modifiable by unidentified environmental factors. We examined the effects of stress on cognitive function in R6/1 HD transgenic mice. Utilizing the Y-maze to assess short-term memory, we report that only female HD mice displayed vulnerability to 1h of confinement stress reflected by impaired memory acquisition. This could not be attributed to a different corticosterone response or exploratory behaviour in the task. This is the first demonstration of increased stress susceptibility in an animal model of HD involving a direct negative impact on cognitive function.
亨廷顿病（HD）是一种神经退行性疾病，其特征为认知、精神和运动能力下降，并可被未明环境因素所修饰。我们研究了应激对 R6/1 HD 转基因小鼠认知功能的影响。通过 Y 迷宫评估短期记忆，我们报告说，只有雌性 HD 小鼠对 1 小时的禁闭应激敏感，表现为记忆获得受损。这不能归因于任务中皮质酮反应或探索行为的不同。这是首例在涉及直接对认知功能产生负面影响的 HD 动物模型中，应激易感性增加的证明。
