School of Biotechnology and Food Engineering, Chuzhou University, Chuzhou 239012, People's Republic of China.
J Ethnopharmacol. 2013 Oct 7;149(3):713-9. doi: 10.1016/j.jep.2013.07.037. Epub 2013 Aug 3.
The immunomodulatory capacities of fresh Cordyceps militaris (FCM) and dry Cordyceps militaris (DCM) were compared.
In vivo immunomodulatory assay, different doses of FCM and DCM were orally administrated over a period of 15 days in a cyclophosphamide (CY) induced immunosuppression mice; in vitro testing, the spleen cells were extracted from healthy mice and treaded with CY, then cultured with different dose of FCM or DCM; the contents of Cordyceps militaris polysaccharide (CMP), cordycepin, adenosine, total polyphenol (TP) and total flavonoids (TF) in FCM and DCM were measured.
Our studys indicated that, FCM was significantly stronger than DCM on increasing the spleen and thymus indexes, spleen lymphocyte activity, macrophage function, and promoting the levels of IL-2, IFN-γ in vivo and in vitro. The contents of immunomodulatory CMP and TF in FCM were markedly higher than in DCM.
All these results suggested that FCM was superior to DCM on enhancing immunity.
比较了新鲜蛹虫草（FCM）和干蛹虫草（DCM）的免疫调节能力。
体内免疫调节试验，将不同剂量的 FCM 和 DCM 经口给予环磷酰胺（CY）诱导免疫抑制的小鼠 15 天；体外试验，从健康小鼠中提取脾细胞，用 CY 处理，然后用不同剂量的 FCM 或 DCM 培养；测量 FCM 和 DCM 中虫草多糖（CMP）、蛹虫草素、腺苷、总多酚（TP）和总黄酮（TF）的含量。
本研究表明，FCM 在提高脾和胸腺指数、脾淋巴细胞活性、巨噬细胞功能以及促进体内和体外 IL-2、IFN-γ水平方面均明显强于 DCM。FCM 中免疫调节 CMP 和 TF 的含量明显高于 DCM。
所有这些结果表明，FCM 在增强免疫力方面优于 DCM。
