Lee Chun-Ting, Huang Keng-Shiang, Shaw Jei-Fu, Chen Jung-Ren, Kuo Wen-Shuo, Shen Gangxu, Grumezescu Alexandru Mihai, Holban Alina Maria, Wang Yi-Ting, Wang Jun-Sheng, Hsiang Yi-Ping, Lin Yu-Mei, Hsu Hsiao-Han, Yang Chih-Hui
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan.
Amulette Chinese Medicine Clinic, Tainan City, Taiwan.
Front Pharmacol. 2020 Nov 30;11:575704. doi: 10.3389/fphar.2020.575704. eCollection 2020.
() is a fungus with a long history of widespread use in folk medicine, and its biological and medicinal functions are well studied. A crucial pharmacological effect of is immunomodulation. In this review, we catalog the immunomodulatory effects of different extracts of , namely total extracts, polysaccharides and cordycepin Total extracts obtained using water or 50% ethyl alcohol and polysaccharides from were discovered to tend to promote type 1 immunity, whereas total extracts obtained using 70-80% ethyl alcohol and cordycepin from were more likely to promote type 2 immunity. This article is the first to classify the immunomodulatory effects of different extracts of . In addition, we discovered a relationship between different segments or extracts and differing types of immunity. This review can provide the readers a comprehensive understanding on the immunomodulatory effects of the precious folk medicine and guidance on its use for both health people and those with an immunodeficiency.
（）是一种在民间医学中有着广泛应用悠久历史的真菌，其生物学和药用功能已得到充分研究。（）的一个关键药理作用是免疫调节。在本综述中，我们梳理了（）不同提取物的免疫调节作用，即总提取物、多糖和虫草素。发现用水或50%乙醇获得的总提取物以及（）中的多糖倾向于促进1型免疫，而用70 - 80%乙醇获得的总提取物和（）中的虫草素更有可能促进2型免疫。本文首次对（）不同提取物的免疫调节作用进行了分类。此外，我们发现了不同部位或提取物与不同类型免疫之间的关系。本综述可为读者提供对这种珍贵民间药物免疫调节作用的全面理解，并为健康人群和免疫缺陷人群使用该药物提供指导。
