Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Finland.
Auton Neurosci. 2013 Oct;177(2):280-5. doi: 10.1016/j.autneu.2013.06.001. Epub 2013 Jul 31.
Emotional excitement may trigger cardiovascular (CV) events, particularly in patients with coronary artery disease (CAD). Our aim was to compare changes in various biomarkers in CAD patients and age-matched healthy male subjects during "real-life" emotional excitement. Enthusiastic male ice hockey spectators (CAD n = 18, healthy subjects n = 16) attended Finnish national ice hockey play-off matches. Heart rate variability, plasma catecholamines, endothelin-1 (ET-1) and interleukin-6 (IL-6) were determined at the baseline and during the match. A significantly more marked increase in both ET-1 and IL-6 was observed in CAD patients compared with healthy subjects during the match (time × group interaction p = 0.009 and p = 0.018 for ET-1 and IL-6, respectively). The high-frequency power of R-R intervals decreased in CAD patients (p<0.001) but did not change in healthy subjects (p = ns, time × group interaction p<0.001). Changes in adrenaline and noradrenaline did not differ between the groups. Emotional excitement causes more marked increases of markers of vasoconstriction and acute inflammation and withdrawal of cardiac vagal regulation in patients with CAD.
情绪激动可能引发心血管 (CV) 事件，尤其是在患有冠状动脉疾病 (CAD) 的患者中。我们的目的是比较 CAD 患者和年龄匹配的健康男性在“现实生活”中的情绪激动期间各种生物标志物的变化。热情的男性冰球观众（CAD 患者 18 名，健康受试者 16 名）参加了芬兰国家冰球季后赛。在基线和比赛期间测定了心率变异性、血浆儿茶酚胺、内皮素-1 (ET-1) 和白细胞介素-6 (IL-6)。与健康受试者相比，在比赛期间，CAD 患者的 ET-1 和 IL-6 均明显增加（时间×组间交互作用 p = 0.009 和 p = 0.018，分别为 ET-1 和 IL-6）。CAD 患者的 R-R 间期高频功率降低（p<0.001），但健康受试者无变化（p = ns，时间×组间交互作用 p<0.001）。两组之间肾上腺素和去甲肾上腺素的变化没有差异。情绪激动会导致 CAD 患者的血管收缩和急性炎症标志物更明显增加，并导致心脏迷走神经调节的丧失。
