Functionality Evaluation Research Group, Korea Food Research Institute, Seongnam 463-746, Korea.
Molecules. 2013 Aug 2;18(8):9241-52. doi: 10.3390/molecules18089241.
This study evaluated the anti-obesity effects of Artemisia capillaris extracts in high-fat diet (HFD)-induced obese rats. After six weeks feeding with HFD, Wistar male rats (12-weeks-old) were divided into three groups: HFD-control group and HFD mixed with 0.4% and 0.8% Artemisia capillaris extracts treated groups. After seven weeks of treatments, the body weight gain of the 0.4% and 0.8% A. capillaris extracts treated groups were significantly less than that of the HFD-control group by 11.8% and 15.4%, respectively. Also, A. capillaris extracts treated groups showed significantly lower serum TG, TC and LDL-c levels in a dose-related manner, while causing the reverse effect in serum HDL-c, and exhibited a hepatoprotective effects in vivo, indicated by reduced hepatic lipid contents, and serum ALT and AST levels. These results show that A. capillaris extracts may prevent body weight increases and improve dyslipidemia in HFD-induced obese rats by enhancing their lipid metabolism.
本研究评估了青蒿提取物对高脂肪饮食（HFD）诱导肥胖大鼠的抗肥胖作用。在喂食 HFD 六周后，Wistar 雄性大鼠（12 周龄）分为三组：HFD 对照组和 HFD 混合 0.4%和 0.8%青蒿提取物处理组。经过七周的治疗，0.4%和 0.8%青蒿提取物处理组的体重增加量分别比 HFD 对照组显著减少了 11.8%和 15.4%。此外，青蒿提取物处理组还表现出剂量依赖性地降低血清 TG、TC 和 LDL-c 水平，而对血清 HDL-c 则产生相反的影响，体内肝脂含量降低，血清 ALT 和 AST 水平也降低，表明其具有肝保护作用。这些结果表明，青蒿提取物可能通过增强脂质代谢来预防体重增加和改善 HFD 诱导肥胖大鼠的血脂异常。
