Hsueh Tun-Pin, Lin Wan-Ling, Dalley Jeffrey W, Tsai Tung-Hu
Institute of Traditional Medicine, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei 112, Taiwan.
School of Traditional Chinese Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Biomedicines. 2021 Oct 8;9(10):1412. doi: 10.3390/biomedicines9101412.
Thunb. ( Yin-Chen in Chinese) is a traditional medicinal herb with a wide spectrum of pharmacological properties ranging from effects against liver dysfunction to treatments of severe cirrhosis and cancer. We used relevant keywords to search electronic databases, including PubMed, Medline, and Google Scholar, for scientific contributions related to this medicinal herb and the pharmacokinetics of its components. The pharmaceutical effects of contribute to the treatment not only of viral hepatitis, cirrhosis, and hepatocellular hepatoma, but also metabolic syndrome, psoriasis, and enterovirus in the clinic. The bioactive compounds, including scoparone, capillarisin, scopoletin, and chlorogenic acid, exhibit antioxidant, anti-inflammatory, antisteatotic, antiviral, and antitumor properties, reflecting the pharmacological effects of . The pharmacokinetics of the main bioactive compounds in can achieve a maximum concentration within 1 hour, but only chlorogenic acid has a relatively long half-life. Regarding the use of the herb by health professionals to treat various diseases, the dosing schedule of this herb should be carefully considered to maximize therapeutic outcomes while lessening possible side effects.
茵陈是一种传统草药，具有广泛的药理特性，从对抗肝功能障碍到治疗严重肝硬化和癌症。我们使用相关关键词搜索电子数据库，包括PubMed、Medline和谷歌学术，以查找与这种草药及其成分药代动力学相关的科学文献。茵陈的药理作用不仅有助于临床治疗病毒性肝炎、肝硬化和肝细胞肝癌，还可治疗代谢综合征、银屑病和肠道病毒。其生物活性化合物，包括滨蒿内酯、茵陈色原酮、东莨菪内酯和绿原酸，具有抗氧化、抗炎、抗脂肪变性、抗病毒和抗肿瘤特性，反映了茵陈的药理作用。茵陈中主要生物活性化合物的药代动力学在1小时内可达到最大浓度，但只有绿原酸具有相对较长的半衰期。关于医疗专业人员使用茵陈草药治疗各种疾病，应仔细考虑该草药的给药方案，以在减少可能的副作用的同时最大化治疗效果。
