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[桥接至心脏搭桥手术;从体外左心室辅助装置转换为植入式左心室辅助装置]

[Bridge to bridge surgery;conversion from extracorporeal left ventricular assist device to implantable left ventricular assist device].

作者信息

Kinoshita Osamu, Ono Minoru

机构信息

Department of Cardiothoracic Surgery, The University of Tokyo, Tokyo, Japan.

出版信息

Kyobu Geka. 2013 Jul;66(8 Suppl):690-5.

Abstract

Implantable left ventricular assist devices(I-LVADs)are approved only for bridge to transplantation (BTT) in the Japanese health insurance system, and paracorporeal Nipro-LVAD is the only one therapeutic choice for bridge to decision( BTD) and bridge to candidacy(BTC).Destination therapy(DT)with an I-LVAD is also not approved in Japan yet. Because average waiting period for heart transplantation is over 2 years, bridge to bridge( BTB) surgery, conversion from Nipro-LVAD to an I-LVAD, is often considered after the patient with Nipro-LVAD is approved by the committee as a heart transplantation recipient. Infection at the exit sites of Nipro-LVAD is a strong risk factor for pump pocket infection after BTB, and therefore BTB is not recommended for patients with Nipro-LVAD who have some infection at the exit sites. To achieve successful BTB, some attention should be made in Nipro-LVAD surgery. For instance, the heart and the outflow vascular graft should be covered with expanded polytetrafluoroethylene (ePTFE) sheet for next safe redo-sternotomy, and the inflow and outflow conduits should be placed appropriately to prevent infection at exit sites. In addition, several examinations and consultation for approval as a heart transplantation recipient should be scheduled as soon as possible after Nipro-LVAD implantation.

摘要

在日本医疗保险体系中,植入式左心室辅助装置(I-LVADs)仅被批准用于心脏移植过渡(BTT),而体外型Nipro-LVAD是心脏移植决策过渡(BTD)和心脏移植候选过渡(BTC)的唯一治疗选择。I-LVAD的终末期治疗(DT)在日本也尚未获批。由于心脏移植的平均等待期超过2年,在使用Nipro-LVAD的患者被委员会批准为心脏移植受者后,常考虑进行桥接至桥接(BTB)手术,即从Nipro-LVAD转换为I-LVAD。Nipro-LVAD出口部位的感染是BTB后泵袋感染的一个重要危险因素,因此,对于Nipro-LVAD出口部位有感染的患者,不建议进行BTB。为了成功实施BTB,在Nipro-LVAD手术中应予以一些注意。例如,为了下次安全的再次开胸手术,心脏和流出血管移植物应覆盖膨体聚四氟乙烯(ePTFE)片,流入和流出管道应适当放置以防止出口部位感染。此外,在植入Nipro-LVAD后,应尽快安排作为心脏移植受者的多项检查和审批咨询。

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