Chilampalli C, Zhang X, Kaushik R S, Young A, Zeman D, Hildreth M B, Fahmy H, Dwivedi C
Departments of Pharmaceutical Sciences, South Dakota State University, Brookings, SD, USA.
Drug Discov Ther. 2013 Jun;7(3):109-15.
α-Santalol is active component of sandalwood oil and has been shown to have chemopreventive effects against chemically and UVB-induced skin cancer development in mice. α-Santalol is also shown to have skin permeation enhancing effects. Honokiol and magnolol isolated from Magnolia officinalis bark extract have also been shown to have chemopreventive effects against chemically and UVB-induced skin cancer in mice. This study was conducted to investigate the combination effects of α-santalol, honokiol and magnolol to study any additive/synergistic effects to lower the doses required for chemoprevention. Pretreatment of combinations of α-santalol with honokiol and magnolol significantly decreased tumor multiplicity upto 75% than control, α-santalol, honokiol and magnolol alone in SKH-1 mice. Combination of α-santalol with honokiol and magnolol also decreased cell viability, proliferation, and enhanced apotosis in comparison to α-santalol, honokiol and magnolol alone in Human epidrmoid carcinoma A431 cells. Overall, the results of present study indicated combinations of α-santalol with honokiol and magnolol could provide chemoprevention of skin cancer at lower doses than given alone.
α-檀香醇是檀香油的活性成分，已被证明对小鼠化学诱导和紫外线诱导的皮肤癌发展具有化学预防作用。α-檀香醇还具有增强皮肤渗透的作用。从厚朴树皮提取物中分离出的和厚朴酚与厚朴酚也已被证明对小鼠化学诱导和紫外线诱导的皮肤癌具有化学预防作用。本研究旨在研究α-檀香醇、和厚朴酚与厚朴酚的联合作用，以探讨是否存在任何相加/协同效应，从而降低化学预防所需的剂量。在SKH-1小鼠中，α-檀香醇与和厚朴酚和厚朴酚联合预处理后，肿瘤多发性比单独使用α-檀香醇、和厚朴酚和厚朴酚时显著降低，最高可达75%。与单独使用α-檀香醇、和厚朴酚和厚朴酚相比，α-檀香醇与和厚朴酚和厚朴酚联合使用还降低了人表皮样癌A431细胞的细胞活力、增殖并增强了凋亡。总体而言，本研究结果表明，α-檀香醇与和厚朴酚和厚朴酚联合使用比单独使用能以更低剂量提供皮肤癌化学预防。
