Department of General Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
Biomed Res Int. 2019 May 23;2019:1847130. doi: 10.1155/2019/1847130. eCollection 2019.
Over years, various biological constituents are isolated from Traditional Chinese Medicine and confirmed to show multifunctional activities. Magnolol, a hydroxylated biphenyl natural compound isolated from , has been extensively documented and shows a range of biological activities. Many signaling pathways include, but are not limited to, NF-B/MAPK, Nrf2/HO-1, and PI3K/Akt pathways, which are implicated in the biological functions mediated by magnolol. Thus, magnolol is considered as a promising therapeutic agent for clinic research. However, the low water solubility, the low bioavailability, and the rapid metabolism of magnolol dramatically limit its clinical application. In this review, we will comprehensively discuss the last five-year progress of the biological activities of magnolol, including anti-inflammatory, antimicroorganism, antioxidative, anticancer, neuroprotective, cardiovascular protection, metabolism regulation, and ion-mediating activity.
多年来，从中药中分离出各种生物成分，并证实它们具有多种功能。厚朴酚是从厚朴中分离出的一种羟基化联苯天然化合物，已被广泛研究，具有多种生物活性。许多信号通路包括但不限于 NF-B/MAPK、Nrf2/HO-1 和 PI3K/Akt 通路，这些通路与厚朴酚介导的生物学功能有关。因此，厚朴酚被认为是一种有前途的临床研究治疗剂。然而，厚朴酚的低水溶性、低生物利用度和快速代谢极大地限制了其临床应用。在这篇综述中，我们将全面讨论厚朴酚在过去五年中的生物活性的最新进展，包括抗炎、抗菌、抗氧化、抗癌、神经保护、心血管保护、代谢调节和离子调节活性。
