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Genetic variability of genes in NER pathway influences the treatment outcome of gastric cancer.核苷酸切除修复（NER）途径中基因的遗传变异性会影响胃癌的治疗结果。
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Potentially functional variants in the core nucleotide excision repair genes predict survival in Japanese gastric cancer patients.核心核苷酸切除修复基因中的潜在功能变体可预测日本胃癌患者的生存情况。
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Current evidences on XPC polymorphisms and gastric cancer susceptibility: a meta-analysis.XPC 多态性与胃癌易感性的研究现状：荟萃分析。
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XPC基因多态性与中国南方人群胃癌易感性

Polymorphisms in the XPC gene and gastric cancer susceptibility in a Southern Chinese population.

作者信息

Hua Rui-Xi, Zhuo Zhen-Jian, Shen Guo-Ping, Zhu Jinhong, Zhang Shao-Dan, Xue Wen-Qiong, Li Xi-Zhao, Zhang Pei-Fen, He Jing, Jia Wei-Hua

机构信息

Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine; Department of Oncology, The First Affiliated Hospital of Sun Yat-sen University.

Department of Traditional Chinese Medicine Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangdong.

出版信息

Onco Targets Ther. 2016 Sep 7;9:5513-9. doi: 10.2147/OTT.S113055. eCollection 2016.

DOI:10.2147/OTT.S113055
PMID:27660469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5019428/
Abstract

Previous studies have reported that XPC gene polymorphisms may modify the individual susceptibility to gastric cancer. In this case-control study with a total of 1,142 cases and 1,173 controls, four potentially functional polymorphisms were genotyped in the XPC gene (rs2228001 A>C, rs2228000 C>T, rs2607775 C>G, and rs1870134 G>C) by Taqman assays and their associations were analyzed with the risk of gastric cancer in a Southern Chinese population. No significant association between any of XPC polymorphisms and gastric cancer risk was detected except for a borderline association with the rs2228000 CT/TT genotype (crude odds ratio =0.86, 95% confidence interval =0.73-1.02, P=0.088) when compared to the rs2228000 CC genotype. Further stratified analysis revealed that the protective effect of rs2228000 CT/TT on the risk of gastric cancer was only significant among subjects older than 58 years. In summary, results indicated that genetic variations in XPC gene may play a weak effect on gastric cancer susceptibility in Southern Chinese population, which warrants further confirmation in larger prospective studies with different ethnic populations.

摘要

先前的研究报告称，XPC基因多态性可能会改变个体对胃癌的易感性。在这项共有1142例病例和1173例对照的病例对照研究中，通过Taqman分析对XPC基因中的四个潜在功能性多态性（rs2228001 A>C、rs2228000 C>T、rs2607775 C>G和rs1870134 G>C）进行基因分型，并分析了它们与中国南方人群胃癌风险的关联。除了与rs2228000 CT/TT基因型存在临界关联（粗比值比=0.86，95%置信区间=0.73-1.02，P=0.088）外，未检测到XPC多态性与胃癌风险之间存在显著关联，该临界关联是与rs2228000 CC基因型相比得出的。进一步的分层分析显示，rs2228000 CT/TT对胃癌风险的保护作用仅在58岁以上的受试者中显著。总之，结果表明XPC基因的遗传变异可能对中国南方人群的胃癌易感性产生微弱影响，这需要在不同种族人群的更大规模前瞻性研究中进一步证实。