Mayo Clinic, Rochester, Minnesota.
J Surg Oncol. 2013 Oct;108(5):275-9. doi: 10.1002/jso.23391. Epub 2013 Aug 5.
Efforts in lung cancer screening with chest X-ray (CXR) and sputum cytology in the 1970s and 1980s were negative. In the ensuing decade, the early lung cancer action project (ELCAP), and the Mayo screening study showed the promise of low-dose CT. These and other studies led to the National lung screening study (NLST), which showed definitively that low-dose spiral computed tomography had a measurable impact on mortality and could be justified as a tool for lung cancer screening. This review examines the results of past and recent studies of lung cancer screening.
20 世纪 70 年代和 80 年代，采用 X 射线（CXR）和痰细胞学检查进行肺癌筛查的努力均未取得成功。在随后的十年中，早期肺癌行动计划（ELCAP）和 Mayo 筛查研究显示了低剂量 CT 的前景。这些研究以及其他研究促成了国家肺癌筛查研究（NLST），该研究明确表明，低剂量螺旋 CT 对死亡率有明显影响，可用作肺癌筛查工具。本文回顾了过去和近期肺癌筛查研究的结果。
