Divisions of Clinical Psychology and Psychiatry, Department of Psychology, University of Basel, Basel, Switzerland.
Pediatrics. 2013 Sep;132(3):483-91. doi: 10.1542/peds.2012-3686. Epub 2013 Aug 5.
Maternal asthma is a common pregnancy complication, with adverse short-term effects for the offspring. The objective was to determine whether asthma during pregnancy is a risk factor of offspring diseases.
We studied pregnant women from the Danish National Birth Cohort (births: 1996-2002; prospective data) giving birth to live singletons (n = 66 712 mother-child pairs), with 4145 (6.2%) women suffering from asthma during pregnancy. We estimated the associations between asthma during pregnancy and offspring diseases (International Classification of Diseases, 10th Revision diagnoses from national registries), controlling for potential confounders and validating findings by secondary analyses.
Offspring median age at end of follow-up was 6.2 (3.6-8.9) years. Asthma was associated with an increased offspring risk of infectious and parasitic diseases (hazard ratio [HR] 1.34; 95% confidence interval [CI] 1.23-1.46), diseases of the nervous system (HR 1.43; CI 1.18-1.73), ear (HR 1.33; CI 1.19-1.48), respiratory system (HR 1.43; CI 1.34-1.52), and skin (HR 1.39; CI 1.20-1.60), and potentially (not confirmed in secondary analyses) of endocrine and metabolic disorders (HR 1.26; CI 1.02-1.55), diseases of the digestive system (HR 1.17; CI 1.04-1.32), and malformations (odds ratio 1.13; CI 1.01-1.26), but not of neoplasms, mental disorders, or diseases of the blood and immune system, circulatory system, musculoskeletal system, and genitourinary system.
To the best of our knowledge, this is the first comprehensive study of the associations between asthma during pregnancy and a wide spectrum of offspring diseases. In line with previous data on selected outcomes, asthma during pregnancy may be a risk factor for numerous offspring diseases, suggesting that careful monitoring of women with asthma during pregnancy and their offspring is important.
母亲哮喘是一种常见的妊娠并发症，对后代有短期不良影响。本研究旨在确定妊娠期间哮喘是否是后代疾病的危险因素。
我们研究了丹麦全国出生队列中的孕妇（1996-2002 年出生；前瞻性数据），她们分娩的是活单胎（n=66712 对母婴），其中 4145 名（6.2%）孕妇在妊娠期间患有哮喘。我们通过控制潜在混杂因素并通过二次分析验证发现，来估计妊娠期间哮喘与后代疾病（来自国家登记处的国际疾病分类，第 10 版诊断）之间的关联。
随访结束时，后代的中位年龄为 6.2 岁（3.6-8.9 岁）。哮喘与传染性和寄生虫病（危险比 [HR] 1.34；95%置信区间 [CI] 1.23-1.46）、神经系统疾病（HR 1.43；CI 1.18-1.73）、耳病（HR 1.33；CI 1.19-1.48）、呼吸系统疾病（HR 1.43；CI 1.34-1.52）和皮肤病（HR 1.39；CI 1.20-1.60）的风险增加有关，且可能（在二次分析中未得到证实）与内分泌和代谢紊乱（HR 1.26；CI 1.02-1.55）、消化系统疾病（HR 1.17；CI 1.04-1.32）和畸形（比值比 1.13；CI 1.01-1.26）有关，但与肿瘤、精神障碍或血液和免疫系统、循环系统、肌肉骨骼系统和生殖泌尿系统疾病无关。
据我们所知，这是首次全面研究妊娠期间哮喘与广泛的后代疾病之间的关联。与以前关于选定结果的数据一致，妊娠期间哮喘可能是许多后代疾病的危险因素，这表明仔细监测妊娠期间患有哮喘的妇女及其后代非常重要。
