Khode V, Rajoor U, Ramdurg S, Ruikar K, Nallulwar S
Department of Physiology, SDM College of Medical Sciences, Sattur, Dharwad, Karnataka, India.
Ann Med Health Sci Res. 2013 Apr;3(2):233-7. doi: 10.4103/2141-9248.113668.
Hypertension on a long-term basis can cause target organ damage, especially the central nervous system, which can affect cognition. It is known that difference between simple and choice reaction time (RT) implies time required for cognition. Although delayed RTs indicate involvement of cognition, they cannot quantify how much time is required for cognition.
Recording chronoscpic RT to quantify time required for cognition in hypertensives and compare them with controls.
This is a hospital-based case-control study conducted (August 2010 to January 2011) on 118 subjects attending an outpatient department using visual and whole body reaction timers having criteria of age and hypertensive condition, compared with an equal number of age- and sex-matched controls. Statistical analysis was carried out by Independent t test and duration of hypertension was correlated with whole body choice reaction time (WBCRT) C1 using Pearson's correlation. Predictive value of WBCRT C1 was calculated by using the receiver operating characteristic curve.
The WBCRT C1 562.6 (108) ms was more delayed among hypertensives compared with controls 523.5(98.8) ms. There was no significant correlation between duration of hypertension and WBCRT C1 (r = -0.064). The best cut-off value for WBCRT C1when predicting cognitive dysfunction in hypertensive patients was 538.5 ms (sensitivity 76.2%, specificity 50%).
WBCRT C1 can be a quantitative measurement of cognition. It can be used as a screening tool to detect cognitive dysfunction.
长期高血压可导致靶器官损害，尤其是中枢神经系统，进而影响认知功能。已知简单反应时间和选择反应时间之间的差异暗示了认知所需的时间。虽然反应时间延迟表明认知功能受到影响，但它们无法量化认知所需的时间。
记录计时反应时间，以量化高血压患者认知所需的时间，并与对照组进行比较。
这是一项基于医院的病例对照研究（2010年8月至2011年1月），对118名门诊患者进行了研究，使用视觉和全身反应计时器，纳入标准为年龄和高血压状况，并与同等数量的年龄和性别匹配的对照组进行比较。采用独立t检验进行统计分析，高血压病程与全身选择反应时间（WBCRT C1）采用Pearson相关性分析。通过绘制受试者工作特征曲线计算WBCRT C1的预测价值。
高血压患者的WBCRT C1为562.6（108）毫秒，比对照组的523.5（98.8）毫秒延迟更明显。高血压病程与WBCRT C1之间无显著相关性（r = -0.064）。预测高血压患者认知功能障碍时，WBCRT C1的最佳截断值为538.5毫秒（敏感性76.2%，特异性50%）。
WBCRT C1可作为认知功能的定量测量指标。它可作为检测认知功能障碍的筛查工具。
