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吸入用药物气雾剂中的静电学

Electrostatics in pharmaceutical aerosols for inhalation.

作者信息

Wong Jennifer, Chan Hak-Kim, Kwok Philip Chi Lip

机构信息

Advanced Drug Delivery Group, The University of Sydney, Camperdown, New South Wales, Australia.

出版信息

Ther Deliv. 2013 Aug;4(8):981-1002. doi: 10.4155/tde.13.70.

DOI:10.4155/tde.13.70
PMID:23919475
Abstract

Electrostatics continues to play an important role in pharmaceutical aerosols for inhalation. Despite its ubiquitous nature, the charging process is complex and not well understood. Nonetheless, significant advances in the past few years continue to improve understanding and lead to better control of electrostatics. The purpose of this critical review is to present an overview of the literature, with an emphasis on how electrostatic charge can be useful in improving pulmonary drug delivery.

摘要

静电学在用于吸入的药物气雾剂中继续发挥着重要作用。尽管其普遍存在,但充电过程复杂且尚未得到充分理解。尽管如此,过去几年的重大进展不断增进我们的理解,并使静电学得到更好的控制。这篇批判性综述的目的是概述相关文献,重点关注静电荷如何有助于改善肺部药物递送。

相似文献

1
Electrostatics in pharmaceutical aerosols for inhalation.吸入用药物气雾剂中的静电学
Ther Deliv. 2013 Aug;4(8):981-1002. doi: 10.4155/tde.13.70.
2
Electrostatics of pharmaceutical inhalation aerosols.药物吸入气溶胶的静电学。
J Pharm Pharmacol. 2009 Dec;61(12):1587-99. doi: 10.1211/jpp/61.12.0002.
3
Electrostatics and inhaled medications: influence on delivery via pressurized metered-dose inhalers and add-on devices.静电与吸入药物:对通过压力定量吸入器及附加装置给药的影响
Respir Care. 2007 Mar;52(3):283-300.
4
Electrostatics of Pharmaceutical Aerosols for Pulmonary Delivery.用于肺部给药的药用气雾剂静电学
Curr Pharm Des. 2015;21(27):3945-54. doi: 10.2174/1381612821666150820110407.
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A new Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) to evaluate pulmonary drug absorption for metered dose dry powder formulations.一种用于细胞培养物的新型药物气溶胶沉积装置(PADDOCC),用于评估计量干粉制剂的肺部药物吸收。
Eur J Pharm Biopharm. 2011 Jan;77(1):132-8. doi: 10.1016/j.ejpb.2010.10.003. Epub 2010 Oct 14.
6
Inhalation therapy with metered-dose inhalers and dry powder inhalers in mechanically ventilated patients.机械通气患者使用定量吸入器和干粉吸入器的吸入疗法。
Respir Care. 2005 Oct;50(10):1331-4; discussion 1344-5.
7
Pharmaceutical aerosol electrostatics: a field with much potential for development.药物气雾剂静电学:一个极具发展潜力的领域。
Ther Deliv. 2015 Feb;6(2):105-7. doi: 10.4155/tde.14.96.
8
Basic techniques for aerosol delivery during mechanical ventilation.机械通气期间气溶胶输送的基本技术。
Respir Care. 2004 Jun;49(6):611-22.
9
Investigation of triboelectric charging in dry powder inhalers using electrical low pressure impactor (ELPI).使用低压电冲击器(ELPI)对干粉吸入器中的摩擦起电进行研究。
Int J Pharm. 2007 May 24;336(2):352-60. doi: 10.1016/j.ijpharm.2006.12.018. Epub 2006 Dec 20.
10
The electrospray and its application to targeted drug inhalation.电喷雾及其在靶向药物吸入中的应用。
Respir Care. 2002 Dec;47(12):1419-31; discussion 1431-3.

引用本文的文献

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Charged Particle Dynamics in Dry Powder Inhalers.干粉吸入器中的带电粒子动力学
Mol Pharm. 2025 Sep 1;22(9):5485-5492. doi: 10.1021/acs.molpharmaceut.5c00485. Epub 2025 Aug 13.
2
Discrete Element Method Evaluation of Triboelectric Charging Due to Powder Handling in the Capsule of a DPI.干粉吸入器胶囊中粉末处理引起的摩擦起电的离散元法评估
Pharmaceutics. 2023 Jun 18;15(6):1762. doi: 10.3390/pharmaceutics15061762.
3
Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions.
不同类型胶囊在不同环境条件下吸入的物理力学性能和静电充电行为评价。
AAPS PharmSciTech. 2020 May 12;21(4):128. doi: 10.1208/s12249-020-01676-2.
4
Tribo-Charging Behaviour of Inhalable Mannitol Blends with Salbutamol Sulphate.可吸入甘露醇混合物与硫酸沙丁胺醇的摩擦带电行为。
Pharm Res. 2019 Apr 9;36(6):80. doi: 10.1007/s11095-019-2612-9.
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Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols.鼻吸入药物气雾剂被动和主动控制下嗅觉给药的建模与模拟
J Vis Exp. 2016 May 20(111):53902. doi: 10.3791/53902.
6
Applicability of Bipolar Charge Analyzer (BOLAR) in Characterizing the Bipolar Electrostatic Charge Profile of Commercial Metered Dose Inhalers (MDIs).双极电荷分析仪(BOLAR)在表征商用定量吸入器(MDIs)双极静电电荷分布方面的适用性。
Pharm Res. 2016 Feb;33(2):283-91. doi: 10.1007/s11095-015-1786-z. Epub 2015 Sep 3.
7
Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis.用于治疗鼻窦炎的带电纳米颗粒靶向输送至窦口鼻道复合体的数值优化。
Int J Nanomedicine. 2015 Jul 30;10:4847-61. doi: 10.2147/IJN.S87382. eCollection 2015.
8
Production of Highly Charged Pharmaceutical Aerosols Using a New Aerosol Induction Charger.使用新型气溶胶感应充电器生产高电荷药物气雾剂
Pharm Res. 2015 Sep;32(9):3007-17. doi: 10.1007/s11095-015-1682-6. Epub 2015 Mar 31.
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Effect of crystallinity on electrostatic charging in dry powder inhaler formulations.结晶度对干粉吸入剂配方中静电充电的影响。
Pharm Res. 2014 Jul;31(7):1656-64. doi: 10.1007/s11095-013-1270-6. Epub 2014 Jan 24.