Pierro Anna, Gaibani Paolo, Manisera Claudia, Rossini Giada, Finarelli Alba Carola, Ghinelli Florio, Macini Pierluigi, Landini Maria Paola, Sambri Vittorio
1 Regional Reference Centre for Microbiological Emergencies (CRREM), of the Operative Unit of Clinical Microbiology, S. Orsola-Malpighi University Hospital , Bologna.
Vector Borne Zoonotic Dis. 2013 Dec;13(12):892-3. doi: 10.1089/vbz.2012.1157. Epub 2013 Aug 6.
The development and persistence of anti-West Nile Virus (WNV) immunoglobulin G (IgG)- and IgM-specific antibodies were investigated in 68 asymptomatic blood donors (BDs) previously tested as positive between October, 2008, and September, 2009, and living in northeastern Italy. Our study showed that WNV-specific IgG titers became negative (41%) or decreased (33%) in a large percentage of BDs, while they increased in a smaller percentage (10%); 16% of BDs showed no titer variation. Reversion to seronegative status within a short time frame suggests that WNV surveillance should be maintained year after year.
对2008年10月至2009年9月期间在意大利东北部生活、之前检测呈阳性的68名无症状献血者（BD）体内抗西尼罗河病毒（WNV）免疫球蛋白G（IgG）和IgM特异性抗体的产生及持续情况进行了研究。我们的研究表明，很大比例的BD体内WNV特异性IgG滴度转为阴性（41%）或下降（33%），而滴度升高的比例较小（10%）；16%的BD滴度无变化。在短时间内恢复到血清阴性状态表明，WNV监测应年复一年地持续进行。
