意大利东北部无症状献血者中抗西尼罗河病毒特异性抗体的持续性

Persistence of anti-West Nile virus-specific antibodies among asymptomatic blood donors in northeastern Italy.

作者信息

Pierro Anna, Gaibani Paolo, Manisera Claudia, Rossini Giada, Finarelli Alba Carola, Ghinelli Florio, Macini Pierluigi, Landini Maria Paola, Sambri Vittorio

机构信息

1 Regional Reference Centre for Microbiological Emergencies (CRREM), of the Operative Unit of Clinical Microbiology, S. Orsola-Malpighi University Hospital , Bologna.

出版信息

Vector Borne Zoonotic Dis. 2013 Dec;13(12):892-3. doi: 10.1089/vbz.2012.1157. Epub 2013 Aug 6.

DOI:10.1089/vbz.2012.1157

PMID:23919606

Abstract

The development and persistence of anti-West Nile Virus (WNV) immunoglobulin G (IgG)- and IgM-specific antibodies were investigated in 68 asymptomatic blood donors (BDs) previously tested as positive between October, 2008, and September, 2009, and living in northeastern Italy. Our study showed that WNV-specific IgG titers became negative (41%) or decreased (33%) in a large percentage of BDs, while they increased in a smaller percentage (10%); 16% of BDs showed no titer variation. Reversion to seronegative status within a short time frame suggests that WNV surveillance should be maintained year after year.

摘要

对2008年10月至2009年9月期间在意大利东北部生活、之前检测呈阳性的68名无症状献血者（BD）体内抗西尼罗河病毒（WNV）免疫球蛋白G（IgG）和IgM特异性抗体的产生及持续情况进行了研究。我们的研究表明，很大比例的BD体内WNV特异性IgG滴度转为阴性（41%）或下降（33%），而滴度升高的比例较小（10%）；16%的BD滴度无变化。在短时间内恢复到血清阴性状态表明，WNV监测应年复一年地持续进行。