脑动脉粥样硬化的老年非痴呆个体中 Aβ42 升高。
Elevated Aβ42 in aged, non-demented individuals with cerebral atherosclerosis.
机构信息
Northwestern University, The Feinberg School of Medicine, Department of Cell and Molecular Biology, 300 East Superior Street Tarry 8-713, Chicago, IL USA 60611-3006.
出版信息
Curr Alzheimer Res. 2013 Oct;10(8):785-9. doi: 10.2174/15672050113109990152.
Abstract
The β-secretase, BACE1, generates β-amyloid (Aβ), a major hallmark of Alzheimer's disease (AD) pathology. The elevation of BACE1 levels in brains of AD patients may play a role in initiating or propagating disease. BACE1 levels are increased under low energy or low oxygen conditions, which may occur in individuals with impaired circulation in the brain. We compared levels of BACE1 in the brains of aged, non-demented individuals with high or low levels of atherosclerosis in the circle of Willis, and found that while there is no change in BACE1, Aβ42 levels are elevated in the high atherosclerosis group.
摘要
β-分泌酶，BACE1，生成β-淀粉样蛋白（Aβ），这是阿尔茨海默病（AD）病理的主要标志。AD 患者大脑中 BACE1 水平的升高可能在启动或传播疾病中发挥作用。在能量或氧气水平低的情况下，BACE1 水平会升高，这可能发生在大脑血液循环受损的个体中。我们比较了大脑中动脉粥样硬化程度高或低的老年、非痴呆个体的 BACE1 水平，发现尽管 BACE1 没有变化，但高动脉粥样硬化组的 Aβ42 水平升高。
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