冲记忆与衰老项目概述及研究结果。
Overview and findings from the rush Memory and Aging Project.
机构信息
Rush Alzheimer's Disease Center, Rush University Medical Center, 600 S. Paulina, Suite 1028, Chicago, IL 60612, USA.
出版信息
Curr Alzheimer Res. 2012 Jul;9(6):646-63. doi: 10.2174/156720512801322663.
Abstract
The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort study of common chronic conditions of aging with an emphasis on decline in cognitive and motor function and risk of Alzheimer's disease (AD). In this manuscript, we first summarize the study design and methods. Then, we present data on: (1) the relation of motor function to cognition, disability, and death; (2) the relation of risk factors to cognitive and motor outcomes, disability and death; (3) the relation of neuropathologic indices to cognitive outcomes; (4) the relation of risk factors to neuropathologic indices; and (5) additional study findings. The findings are discussed and contextualized.
摘要
记忆与衰老项目是一项针对衰老过程中常见慢性疾病的纵向、流行病学临床病理学队列研究，重点是认知和运动功能下降以及阿尔茨海默病（AD）的风险。在本手稿中，我们首先总结了研究设计和方法。然后，我们展示了以下数据：（1）运动功能与认知、残疾和死亡的关系；（2）风险因素与认知和运动结果、残疾和死亡的关系；（3）神经病理指标与认知结果的关系；（4）风险因素与神经病理指标的关系；（5）其他研究发现。对这些发现进行了讨论和背景分析。
相似文献
1
Overview and findings from the rush Memory and Aging Project.冲记忆与衰老项目概述及研究结果。
Curr Alzheimer Res. 2012 Jul;9(6):646-63. doi: 10.2174/156720512801322663.
2
Overview and findings from the religious orders study.宗教秩序研究概述及发现。
Curr Alzheimer Res. 2012 Jul;9(6):628-45. doi: 10.2174/156720512801322573.
3
Much of late life cognitive decline is not due to common neurodegenerative pathologies.晚年认知能力下降的大部分原因并非常见的神经退行性病变。
Ann Neurol. 2013 Sep;74(3):478-89. doi: 10.1002/ana.23964. Epub 2013 Jul 10.
4
Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study.老年人群中脑血管疾病与阿尔茨海默病性痴呆及认知功能的关系：一项横断面研究
Lancet Neurol. 2016 Aug;15(9):934-943. doi: 10.1016/S1474-4422(16)30029-1. Epub 2016 Jun 14.
5
Selected findings from the Religious Orders Study and Rush Memory and Aging Project.宗教机构研究和拉什记忆与衰老项目的部分研究结果。
J Alzheimers Dis. 2013;33 Suppl 1(0):S397-403. doi: 10.3233/JAD-2012-129007.
6
The Honolulu-Asia Aging Study: epidemiologic and neuropathologic research on cognitive impairment.檀香山-亚洲老龄化研究：认知障碍的流行病学和神经病理学研究。
Curr Alzheimer Res. 2012 Jul;9(6):664-72. doi: 10.2174/156720512801322618.
7
Postmortem indices linking risk factors to cognition: results from the Religious Order Study and the Memory and Aging Project.将风险因素与认知联系起来的死后指标：来自宗教秩序研究和记忆与衰老项目的结果。
Alzheimer Dis Assoc Disord. 2006 Jul-Sep;20(3 Suppl 2):S63-8. doi: 10.1097/00002093-200607001-00009.
8
Social Determinants, Race, and Brain Health Outcomes: Findings from the Chicago Health and Aging Project.社会决定因素、种族与大脑健康结果：来自芝加哥健康与衰老项目的发现
Curr Alzheimer Res. 2015;12(7):622-31. doi: 10.2174/1567205012666150701102606.
9
Effect of purpose in life on the relation between Alzheimer disease pathologic changes on cognitive function in advanced age.生活目标对老年期阿尔茨海默病病理变化与认知功能之间关系的影响。
Arch Gen Psychiatry. 2012 May;69(5):499-505. doi: 10.1001/archgenpsychiatry.2011.1487.
10
Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies.老年社区居住的路易体患者认知障碍、衰退和波动。
Brain. 2012 Oct;135(Pt 10):3005-14. doi: 10.1093/brain/aws234.
引用本文的文献
1
A coordinated analysis of bidirectional associations between life satisfaction and cognitive function.生活满意度与认知功能之间双向关联的协同分析。
J Pers Soc Psychol. 2025 Aug 14. doi: 10.1037/pspp0000574.
2
Human brain vascular multi-omics elucidates disease-risk associations.人类脑血管多组学揭示疾病风险关联。
Neuron. 2025 Jul 23. doi: 10.1016/j.neuron.2025.07.001.
3
Combating Genetic Heterogeneity for Polygenic Prediction of Susceptibility to Brain β-Amyloid Deposition: Beyond .对抗基因异质性以进行脑β淀粉样蛋白沉积易感性的多基因预测：超越……
Neurol Genet. 2025 Jul 21;11(4):e200266. doi: 10.1212/NXG.0000000000200266. eCollection 2025 Aug.
4
Sex differences in modifiable dementia risk factors: Findings from the Rush Memory and Aging Project.可改变的痴呆风险因素中的性别差异：拉什记忆与衰老项目的研究结果
Alzheimers Dement. 2025 Jul;21(7):e70506. doi: 10.1002/alz.70506.
5
Morphometric characteristics of tibial nerve and their relationship with age.胫神经的形态测量特征及其与年龄的关系。
Brain Commun. 2025 Jul 7;7(4):fcaf267. doi: 10.1093/braincomms/fcaf267. eCollection 2025.
6
Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer's disease: implications for microglia activation and sex differences.用于理解阿尔茨海默病患者大脑分子变化的可解释深度学习框架：对小胶质细胞激活和性别差异的启示
NPJ Aging. 2025 Jul 16;11(1):66. doi: 10.1038/s41514-025-00258-5.
7
Sex Differences in Associations of Lewy Body Disease with Alzheimer's Disease and Cognitive Decline.路易体病与阿尔茨海默病及认知衰退关联中的性别差异
Ann Neurol. 2025 Jul 11. doi: 10.1002/ana.27308.
8
Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease.种族化对阿尔茨海默病神经影像学和血浆生物标志物的影响。
Alzheimers Dement. 2025 Jul;21(7):e70463. doi: 10.1002/alz.70463.
9
An international multi-cohort investigation of self-reported sleep and future depressive symptoms in older adults.一项关于老年人自我报告的睡眠情况与未来抑郁症状的国际多队列调查。
Sci Rep. 2025 Jul 4;15(1):23918. doi: 10.1038/s41598-025-07864-z.
10
The dynamics of cognitive decline toward Alzheimer's disease progression: Results from ADSP-PHC's harmonized cognitive composites.向阿尔茨海默病进展过程中认知衰退的动态变化：来自ADSP-PHC协调认知综合指标的结果。
Alzheimers Dement. 2025 Jun;21(6):e70335. doi: 10.1002/alz.70335.
本文引用的文献
1
Neuroticism, extraversion, and motor function in community-dwelling older persons.社区老年人的神经质、外向性和运动功能。
Am J Geriatr Psychiatry. 2013 Feb;21(2):145-54. doi: 10.1016/j.jagp.2012.10.015. Epub 2013 Jan 22.
2
Explaining differences in episodic memory performance among older African Americans and Whites: the roles of factors related to cognitive reserve and test bias.解释老年非裔美国人和白人在情景记忆表现上的差异：与认知储备和测试偏差相关的因素的作用。
J Int Neuropsychol Soc. 2011 Jul;17(4):625-38. doi: 10.1017/S1355617711000476.
3
Cognitive activities during adulthood are more important than education in building reserve.成年后的认知活动比教育更重要，可以帮助建立大脑储备。
J Int Neuropsychol Soc. 2011 Jul;17(4):615-24. doi: 10.1017/S1355617711000014.
4
Effect of purpose in life on the relation between Alzheimer disease pathologic changes on cognitive function in advanced age.生活目标对老年期阿尔茨海默病病理变化与认知功能之间关系的影响。
Arch Gen Psychiatry. 2012 May;69(5):499-505. doi: 10.1001/archgenpsychiatry.2011.1487.
5
Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals.静息-活动模式碎片化增加与老年人认知障碍的特征模式相关。
Sleep. 2012 May 1;35(5):633-40B. doi: 10.5665/sleep.1820.
6
Total daily physical activity and the risk of AD and cognitive decline in older adults.总的日常身体活动与老年人 AD 和认知能力下降的风险。
Neurology. 2012 Apr 24;78(17):1323-9. doi: 10.1212/WNL.0b013e3182535d35. Epub 2012 Apr 18.
7
Influence of late-life cognitive activity on cognitive health.晚年认知活动对认知健康的影响。
Neurology. 2012 Apr 10;78(15):1123-9. doi: 10.1212/WNL.0b013e31824f8c03. Epub 2012 Apr 4.
8
Total daily physical activity and longevity in old age.老年人的每日总身体活动量与长寿
Arch Intern Med. 2012 Mar 12;172(5):444-6. doi: 10.1001/archinternmed.2011.1477.
9
Nigral pathology and parkinsonian signs in elders without Parkinson disease.老年人群中无帕金森病患者的黑质病理与帕金森病体征。
Ann Neurol. 2012 Feb;71(2):258-66. doi: 10.1002/ana.22588.
10
Genetic variation at CR1 increases risk of cerebral amyloid angiopathy.CR1 上的遗传变异增加了脑淀粉样血管病的风险。
Neurology. 2012 Jan 31;78(5):334-41. doi: 10.1212/WNL.0b013e3182452b40. Epub 2012 Jan 18.
Zotero 插件