Rush Alzheimer's Disease Center, Rush University Medical Center, 600 S. Paulina, Suite 1028, Chicago, IL 60612, USA.
Curr Alzheimer Res. 2012 Jul;9(6):646-63. doi: 10.2174/156720512801322663.
The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort study of common chronic conditions of aging with an emphasis on decline in cognitive and motor function and risk of Alzheimer's disease (AD). In this manuscript, we first summarize the study design and methods. Then, we present data on: (1) the relation of motor function to cognition, disability, and death; (2) the relation of risk factors to cognitive and motor outcomes, disability and death; (3) the relation of neuropathologic indices to cognitive outcomes; (4) the relation of risk factors to neuropathologic indices; and (5) additional study findings. The findings are discussed and contextualized.
记忆与衰老项目是一项针对衰老过程中常见慢性疾病的纵向、流行病学临床病理学队列研究,重点是认知和运动功能下降以及阿尔茨海默病(AD)的风险。在本手稿中,我们首先总结了研究设计和方法。然后,我们展示了以下数据:(1)运动功能与认知、残疾和死亡的关系;(2)风险因素与认知和运动结果、残疾和死亡的关系;(3)神经病理指标与认知结果的关系;(4)风险因素与神经病理指标的关系;(5)其他研究发现。对这些发现进行了讨论和背景分析。