The Berlin Aging Study II; Research Group on Geriatrics; Charité - Universitätsmedizin Berlin, Berlin, Germany.
DNA Repair (Amst). 2013 Oct;12(10):811-6. doi: 10.1016/j.dnarep.2013.07.005. Epub 2013 Aug 3.
While the pathogenesis of the sporadic form of Alzheimer disease (late onset Alzheimer disease, LOAD) is not fully understood, it seems to be clear that a combination of genetic and environmental factors are involved and influence the course of the disease. Among these factors, elevated levels of oxidative stress have been recognized and individual differences in the capacity to deal with DNA damage caused by its effects have been the subject of numerous studies. This review summarizes the research on DNA repair proteins and genes in the context of LOAD pathogenesis and its possible prodromal stage, mild cognitive impairment (MCI). The current status of the research in this field is discussed with respect to methodological issues which might have compromised the outcome of some studies and future directions of investigation on this subject are depicted.
虽然散发性阿尔茨海默病（晚发性阿尔茨海默病，LOAD）的发病机制尚未完全阐明，但似乎可以明确的是，遗传和环境因素的组合参与并影响疾病的进程。在这些因素中，氧化应激水平升高已得到公认，而个体对其影响引起的 DNA 损伤的处理能力的差异则是众多研究的主题。 本综述总结了 DNA 修复蛋白和基因在 LOAD 发病机制及其可能的前驱阶段（轻度认知障碍，MCI）中的研究。 讨论了该领域研究的现状，涉及可能影响某些研究结果的方法学问题，并描绘了该主题的未来研究方向。
