Department of Endocrinology, Royal Free London NHS Foundation Trust, Pond Street, London NW3 2QG, UK.
Br Med Bull. 2013;107:101-16. doi: 10.1093/bmb/ldt024. Epub 2013 Aug 6.
Subclinical thyroid disease is a common finding on testing of thyroid function and its management remains controversial.
Epidemiological data from large population studies from USA and Europe.
There is an increased risk of progression to overt hypothyroidism or hyperthyroidism. The treatment of mild thyroid failure is of importance in optimizing pregnancy outcome.
Diagnostic criteria differ and there is variation between management guidelines. The difference was found in long-term clinical outcomes between endogenous and exogenous subclinical hyperthyroidism.
Meta-analyses have provided epidemiological data in cardiovascular mortality and morbidity in subclinical thyroid disease. Increased use of echocardiography and bone markers in identifying those who benefit from intervention.
A randomized controlled trial to identify those subjects identified from screening programmes that benefit from intervention in terms of morbidity and mortality.
亚临床甲状腺疾病是甲状腺功能检测中的常见发现，其治疗仍存在争议。
来自美国和欧洲大型人群研究的流行病学数据。
存在向显性甲状腺功能减退或甲状腺功能亢进发展的风险增加。轻度甲状腺功能衰竭的治疗对于优化妊娠结局非常重要。
诊断标准不同，管理指南之间存在差异。在内源性和外源性亚临床甲状腺功能亢进症之间发现了长期临床结局的差异。
荟萃分析提供了亚临床甲状腺疾病心血管死亡率和发病率的流行病学数据。越来越多地使用超声心动图和骨标志物来确定那些受益于干预的患者。
进行一项随机对照试验，以确定从筛查计划中确定的那些从发病率和死亡率方面受益于干预的患者。
