Gupta Sangeeta, Kaiti Rajesh, Gupta Gaurav
Associate Professor, Department of Physiology, Maharishi Markandeshwar Institute of Medical Sciences and Research (M.M.I.M.S.R), Mullana-Ambala, Haryana, India.
Postgraduate Student, Department of Physiology, Maharishi Markandeshwar Institute of Medical Sciences and Research (M.M.I.M.S.R), Mullana-Ambala, Haryana, India.
J Clin Diagn Res. 2017 Jun;11(6):CC13-CC16. doi: 10.7860/JCDR/2017/25604.9989. Epub 2017 Jun 1.
Hypothyroidism, a common endocrinological disorder is quite prevalent in its subclinical state in the adult population. Nervous system involvement is frequent in hypothyroidism with documentation of peripheral and central conduction delays as abnormal latency prolongations in Brainstem Auditory Evoked Potential (BAEP) records. Subclinical hypothyroidism however, has been less extensively studied for investigating the involvement of the auditory functions.
To assess the auditory functions and Central Nervous System (CNS) involvement in the patients with subclinical hypothyroidism by recording BAEP.
The study comprised of 50 females (25 females with subclinical hypothyroidism and 25 age-matched healthy females) in the age-group of 30-50 years. BAEP absolute and Interpeak Latencies (IPLs) (I, III and V, I-III, III-V and I-V) were compared between the two groups by unpaired t-test. The p<0.05 was considered as statistically significant.
Mean BAEP absolute latencies (III and V) increased in the subjects with subclinical hypothyroidism as compared to controls (p<0.001) (both the ears) and wave I absolute latency also increased with p<0.001 (both the ears) by unpaired t-test. Among IPLs (interpeak latencies), III-V and I-V IPLs exhibited increase (p<0.01), while I-III IPL did not vary with statistical significance (both the ears) in the two groups.
Patients with subclinical hypothyroidism were found to demonstrate central as well as peripheral auditory pathway affections. BAEPs can prove valuable and sensitive tests to detect involvement of the CNS and auditory dysfunctions earlier in hypothyroidism.
甲状腺功能减退症是一种常见的内分泌疾病，在成年人群的亚临床状态中相当普遍。甲状腺功能减退症常累及神经系统，脑干听觉诱发电位（BAEP）记录显示外周和中枢传导延迟，表现为异常的潜伏期延长。然而，对于亚临床甲状腺功能减退症患者听觉功能受累情况的研究较少。
通过记录BAEP评估亚临床甲状腺功能减退症患者的听觉功能及中枢神经系统（CNS）受累情况。
本研究纳入了50名年龄在30至50岁之间的女性（25名亚临床甲状腺功能减退症女性和25名年龄匹配的健康女性）。通过非配对t检验比较两组之间的BAEP绝对潜伏期和峰间潜伏期（IPLs）（I、III和V、I-III、III-V和I-V）。p<0.05被认为具有统计学意义。
与对照组相比，亚临床甲状腺功能减退症患者的平均BAEP绝对潜伏期（III和V）增加（p<0.001）（双耳），波I绝对潜伏期也增加，非配对t检验显示p<0.001（双耳）。在IPLs（峰间潜伏期）中，III-V和I-V IPLs增加（p<0.01），而两组中I-III IPL在统计学上无显著差异（双耳）。
发现亚临床甲状腺功能减退症患者存在中枢和外周听觉通路病变。BAEP可作为有价值且敏感的检测方法，更早地发现甲状腺功能减退症患者的CNS受累及听觉功能障碍。
