Jimoh Ahmed Kayode, Ghazal Muritala Segun, Adeleke Adewoyin Babajide, Adeniyi Adebayo Augustine, Adebara Idowu Oluseyi, Babalola Fatai Olakunle, Ajani Gbadebo Oladimeji, Agboola Matthew Segun, Busari Olusegun Adesola
Department of Chemical Pathology, College of Medicine and Health Sciences, Afe Babalola University, AdoEkiti, Federal Teaching Hospital, IdoEkiti Annex, Ekiti State, Nigeria.
Department of Chemical Pathology, Federal Teaching Hospital, IdoEkiti, Ekiti State, Nigeria.
Ann Afr Med. 2020 Apr-Jun;19(2):89-94. doi: 10.4103/aam.aam_31_19.
Thyroid disorders are one of the most common endocrine disorders seen globally. Diagnostic challenge may arise both clinically and biochemically because of the multiple function of thyroid hormones (THs). Request for thyroid function test (TFT s) may be based on clinical impression that may suggest thyroid dysfunction or obvious symptoms and signs that are diagnostic of hyperthyroidism or hypothyroidism.
This retrospective study looks at the biochemical patterns of TFTs and the clinical impression of thyroid disorders in a rural tertiary institution. Information extracted from the laboratory register includes indication for the test, the hospital number, the gender, the age, and the THs assayed. The corresponding biochemical pattern of the TFT result was established.
A total of 297 requests were submitted for TH assay; 34 were excluded from the present study because there were no clinical information. There were 239 females and 24 males giving a female-to-male ratio of 9.9:1. Majority of the requests (36.5%) were for goiters, followed by gynecological disorders (20.9%) and clinical thyroid disorders (17.9%). About 46% (45.8%) of the goiter cases were biochemically euthyroid, whereas 13.5% were biochemically primary hyperthyroid. Among the 47 cases of thyroid disorders by the physician's clinical impression, 27.7% were euthyroid, 17% were biochemically hyperthyroid, and 10.6% were hypothyroid. Of the 55 gynecological disorders assessed, only 7.3% show biochemical evidence of TH alteration with 56.4% being euthyroid. About 47% (46.6%) of those that did routine medical examination had altered TH level that includes hyperthyroidism and hypothyroidism.
Goiter is the most prevalent thyroid disorder in this environment. Biochemical pattern of thyroid function test in our environment was mostly euthyroid despites clinical features suggestive of thyroid disorders.
甲状腺疾病是全球最常见的内分泌疾病之一。由于甲状腺激素（THs）具有多种功能，在临床和生化方面都可能出现诊断挑战。甲状腺功能测试（TFTs）的申请可能基于提示甲状腺功能障碍的临床印象，或基于诊断甲亢或甲减的明显症状和体征。
这项回顾性研究观察了一家农村三级医疗机构中TFTs的生化模式以及甲状腺疾病的临床印象。从实验室登记册中提取的信息包括测试指征、医院编号、性别、年龄以及所检测的THs。确定了TFT结果相应的生化模式。
共提交了297份TH检测申请；本研究排除了34份，因为没有临床信息。有239名女性和24名男性，女性与男性的比例为9.9:1。大多数申请（36.5%）是针对甲状腺肿，其次是妇科疾病（20.9%）和临床甲状腺疾病（17.9%）。约46%（45.8%）的甲状腺肿病例生化检查甲状腺功能正常，而13.5%为生化原发性甲亢。在医生临床诊断为甲状腺疾病的47例病例中，27.7%甲状腺功能正常，17%生化检查为甲亢，10.6%为甲减。在评估的55例妇科疾病中，只有7.3%显示有TH改变的生化证据，56.4%甲状腺功能正常。约47%（46.6%）进行常规体检的人TH水平有改变，包括甲亢和甲减。
甲状腺肿是该地区最常见的甲状腺疾病。尽管有提示甲状腺疾病的临床特征，但我们地区甲状腺功能测试的生化模式大多为甲状腺功能正常。
