Laboratory of Immunology and Inflammation, Research Center of Basic Medical Science, Tianjin Medical Univerity, Tianjin, China; Department of Immunology, Basic Medical College, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin, China; Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China, Tianjin Medical University, Tianjin, China.
Cancer Lett. 2013 Oct 28;340(1):124-33. doi: 10.1016/j.canlet.2013.07.038. Epub 2013 Aug 3.
Cancer immunoediting consists of three distinct phases: elimination, equilibrium and escape. Here, for the first time, we investigated the immune microenvironment profiles of tumor immune equilibrium and immune escape states in 3'-methylcholanthrene-induced murine sarcoma model. Our study indicates the relative balance of monocytic MDSCs and antitumor immunity cells (especially CTLs, NK cells and γδT cells) may involve in maintaining tumor cells in a state of immune-mediated dormancy. In addition, high percentages of Treg cells and PMN-MDSCs are associated with the tumor immune escape state - mice with progressing sarcomas. In summary, the relative balance of immune effector cells and suppressive populations in the tumor microenvironment may involve in determining the fate of tumors.
消除、平衡和逃逸。在这里，我们首次研究了 3'-甲基胆蒽诱导的鼠肉瘤模型中肿瘤免疫平衡和免疫逃逸状态的免疫微环境特征。我们的研究表明，单核细胞 MDSC 和抗肿瘤免疫细胞（特别是 CTL、NK 细胞和 γδT 细胞）的相对平衡可能涉及维持肿瘤细胞处于免疫介导的休眠状态。此外，高比例的 Treg 细胞和 PMN-MDSC 与肿瘤免疫逃逸状态相关-进展性肉瘤的小鼠。总之，肿瘤微环境中免疫效应细胞和抑制性群体的相对平衡可能涉及决定肿瘤的命运。
