Tyndall D A
Dept. of Diagnostic Sciences, University of North Carolina, School of Dentistry, Chapel Hill 27514-7450.
Magn Reson Imaging. 1990;8(4):423-33. doi: 10.1016/0730-725x(90)90051-3.
This investigation was undertaken in order to ascertain the combined effects of magnetic resonance imaging (MRI) fields and x-irradiation on the developing eye of the mouse strain C57B1/6J. Dams in groups of 15 were subjected to absorbed doses of 5, 15, and 30 cGy. Other dams (N = 15) were exposed to T2 spin-echo MRI fields under clinically realistic conditions following exposure to 30 cGy of x-irradiation. The developing eye was the biological end point studied. It was found that the 30-cGy dose resulted in teratogenic significance (p less than or equal to .05) for the C57B1/6J mouse. Groups exposed to both types of radiation fields demonstrated malformation levels similar to the 30-cGy irradiated animals with no additive or synergistic effects detected. The malformation rates and degree of statistical significance varied somewhat with unit of measurement, and analytical method. The results confirmed low level X-ray teratogenicity and suggested that the MRI techniques employed for this investigation did not enhance the teratogenicity of x-irradiation on eye malformations produced in the C57B1/6J mouse.
进行这项研究是为了确定磁共振成像（MRI）场和X射线辐射对C57B1/6J小鼠发育中的眼睛的联合影响。将15只一组的母鼠给予5、15和30 cGy的吸收剂量。其他母鼠（N = 15）在接受30 cGy的X射线辐射后，在临床实际条件下暴露于T2自旋回波MRI场。发育中的眼睛是所研究的生物学终点。结果发现，30 cGy的剂量对C57B1/6J小鼠具有致畸意义（p小于或等于0.05）。暴露于两种辐射场的组表现出与30 cGy辐射动物相似的畸形水平，未检测到相加或协同效应。畸形率和统计显著性程度随测量单位和分析方法而有所不同。结果证实了低水平X射线的致畸性，并表明本研究中使用的MRI技术不会增强X射线辐射对C57B1/6J小鼠产生眼睛畸形的致畸性。
