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真菌凝集素:结构、功能与潜在应用。

Fungal lectins: structure, function and potential applications.

机构信息

CERMAV-CNRS (UPR5301, Affiliated with Université Grenoble Alpes and Belonging to ICMG), BP53, F8041 Grenoble cedex 9, France.

出版信息

Curr Opin Struct Biol. 2013 Oct;23(5):678-85. doi: 10.1016/j.sbi.2013.07.007. Epub 2013 Aug 3.

Abstract

Lectins are a widespread class of proteins implicated in many essential cellular and molecular recognition processes. They recognize carbohydrates in a non-catalytic, specific and reversible manner. Fungi, which include mushrooms, microfungi and yeasts, have attracted wide interest in recent years. They are indeed a promising source for novel lectins with unique specificity and potential for biomedical and biotechnological applications. Information on fungal lectins, particularly structural insight, is scarce compared to that on their plant and animal counterparts. This review therefore focuses on the structure, function, and exploitable properties of fungal lectins.

摘要

凝集素是一类广泛存在的蛋白质,参与许多重要的细胞和分子识别过程。它们以非催化、特异性和可逆的方式识别碳水化合物。近年来,真菌(包括蘑菇、微生物和酵母)引起了广泛的关注。它们确实是新型凝集素的有前途的来源,具有独特的特异性和在生物医学和生物技术应用方面的潜力。与植物和动物凝集素相比,真菌凝集素的信息,特别是结构方面的信息相对较少。因此,本文重点介绍真菌凝集素的结构、功能和可开发特性。

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