输卵管结扎与绝经症状和乳腺癌风险的关系。
Tubal ligation in relation to menopausal symptoms and breast cancer risk.
机构信息
Epidemiology Branch, National Institute of Environmental Health Sciences, PO Box 12233, 111 TW Alexander Drive, MD A3-05, Research Triangle Park, NC 27709, USA.
出版信息
Br J Cancer. 2013 Sep 3;109(5):1291-5. doi: 10.1038/bjc.2013.433. Epub 2013 Aug 6.
Abstract
BACKGROUND
Local inflammation after tubal ligation may affect ovarian function and breast cancer risk.
METHODS
We analysed tubal ligation, menopausal characteristics, and breast cancer risk in the Sister Study cohort (N=50,884 women).
RESULTS
Tubal ligation was associated with hot flashes (hazard ratio (HR) 1.09; 95% confidence interval (CI): 1.06-1.12) but not menopausal age (HR 0.99; 95% CI: 0.96-1.02). Tubal ligation did not have an impact on breast cancer overall (HR 0.95; 95% CI: 0.85-1.06), but had a suggested inverse relation with oestrogen receptor+/progesterone receptor+ invasive tumours (HR 0.84; 95% CI: 0.70-1.01), possibly because of subsequent hysterectomy/bilateral oophorectomy.
CONCLUSION
Tubal ligation does not influence overall breast cancer risk.
摘要
背景
输卵管结扎后的局部炎症可能会影响卵巢功能和乳腺癌风险。
方法
我们分析了姐妹研究队列（50884 名女性）中的输卵管结扎、绝经特征和乳腺癌风险。
结果
输卵管结扎与热潮红相关（风险比 (HR) 1.09；95%置信区间 (CI)：1.06-1.12），但与绝经年龄无关（HR 0.99；95% CI：0.96-1.02）。输卵管结扎对总体乳腺癌没有影响（HR 0.95；95% CI：0.85-1.06），但与雌激素受体+/孕激素受体+浸润性肿瘤呈负相关（HR 0.84；95% CI：0.70-1.01），可能是因为随后的子宫切除术/双侧卵巢切除术。
结论
输卵管结扎不会影响总体乳腺癌风险。
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