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本文引用的文献

1
Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: intent-to-treat analysis and efficacy after failure to prior immunotherapies.转移性黑色素瘤患者肿瘤浸润淋巴细胞的过继转移：既往免疫治疗失败后的意向治疗分析和疗效。
Clin Cancer Res. 2013 Sep 1;19(17):4792-800. doi: 10.1158/1078-0432.CCR-13-0380. Epub 2013 May 20.
2
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.嵌合抗原受体修饰的 T 细胞治疗急性淋巴细胞白血病。
N Engl J Med. 2013 Apr 18;368(16):1509-1518. doi: 10.1056/NEJMoa1215134. Epub 2013 Mar 25.
3
Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients.特异性淋巴细胞亚群预测转移性黑色素瘤患者接受扩增自体肿瘤浸润淋巴细胞过继细胞治疗的反应。
Clin Cancer Res. 2012 Dec 15;18(24):6758-70. doi: 10.1158/1078-0432.CCR-12-1177. Epub 2012 Oct 2.
4
The blockade of immune checkpoints in cancer immunotherapy.癌症免疫疗法中的免疫检查点阻断。
Nat Rev Cancer. 2012 Mar 22;12(4):252-64. doi: 10.1038/nrc3239.
5
Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype.转移的黑色素瘤特异性 CD8+ T 细胞持续存在，介导肿瘤消退，并获得中央记忆表型。
Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4592-7. doi: 10.1073/pnas.1113748109. Epub 2012 Mar 5.
6
Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells.利用体外培养的 CD8+ T 细胞在人体内建立抗肿瘤记忆。
Sci Transl Med. 2011 Apr 27;3(80):80ra34. doi: 10.1126/scitranslmed.3002207.
7
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy.采用 T 细胞转移免疫疗法治疗转移性黑色素瘤的大量预处理患者中持久的完全应答。
Clin Cancer Res. 2011 Jul 1;17(13):4550-7. doi: 10.1158/1078-0432.CCR-11-0116. Epub 2011 Apr 15.
8
Minimally cultured tumor-infiltrating lymphocytes display optimal characteristics for adoptive cell therapy.经过最低限度培养的肿瘤浸润淋巴细胞表现出用于过继性细胞治疗的最佳特性。
J Immunother. 2008 Oct;31(8):742-51. doi: 10.1097/CJI.0b013e31818403d5.
9
Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1.用针对NY-ESO-1的自体CD4+ T细胞治疗转移性黑色素瘤。
N Engl J Med. 2008 Jun 19;358(25):2698-703. doi: 10.1056/NEJMoa0800251.
10
IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response.白细胞介素-21影响抗原特异性CD8 T细胞反应的频率、表型和亲和力。
J Immunol. 2005 Aug 15;175(4):2261-9. doi: 10.4049/jimmunol.175.4.2261.

嵌合抗原受体 T 细胞疗法治疗癌症：小众疗法还是治疗模式？

Adoptive T-cell therapy for cancer: boutique therapy or treatment modality?

机构信息

Department of Melanoma, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.

出版信息

Clin Cancer Res. 2013 Sep 1;19(17):4550-2. doi: 10.1158/1078-0432.CCR-13-1367. Epub 2013 Aug 6.

DOI:10.1158/1078-0432.CCR-13-1367
PMID:23922301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3830944/
Abstract

Adoptive cellular therapy, involving the ex vivo enrichment and expansion of antigen-specific immune cells for adoptive transfer, has emerged as an increasingly effective modality for the treatment of patients with advanced cancer refractory to conventional therapy.

摘要

过继细胞疗法，包括体外抗原特异性免疫细胞的富集和扩增，以进行过继转移，已成为治疗对常规治疗无效的晚期癌症患者的一种越来越有效的方法。