Ibrahim Mohammed Auwal, Koorbanally Neil Anthony, Islam Md Shahidul
School of Life Sciences, University of KwaZulu-Natal (Westville Campus), Durban 4000, South Africa.
Acta Pol Pharm. 2013 Jul-Aug;70(4):709-19.
The present study was conducted to investigate the anti-oxidative activities of different solvent extracts of Cassia singueana parts. Our results indicate that all the extracts have reducing power (Fe3+ --> Fe2+) and DPPH radical scavenging abilities. However, the ethyl acetate extract of the stem bark has the highest total reducing power whilst the ethanol extract of the stem bark has more potent free radical scavenging activity than all the other extracts. The ethyl acetate extract of the stem bark exhibited more powerful hydroxyl radical scavenging activity than other extracts whilst the aqueous extract of the leaves displayed more potent nitric oxide inhibition activity than other extracts. The GC-MS analysis of the ethyl acetate extract of the stem bark and the ethanol extract of the root and leaves indicated that several aromatic compounds, including phenolics, fatty acids, amino acids and triterpenoids were present in these extracts. Data from this study suggest that the parts of C. singueana possessed anti-oxidative activities and can be used as a potential alternative medicine for oxidative stress related non-communicable chronic diseases. Further experimental and clinical studies in this regard are warranted.
本研究旨在调查Cassia singueana各部位不同溶剂提取物的抗氧化活性。我们的结果表明，所有提取物均具有还原能力（Fe3+→Fe2+）和DPPH自由基清除能力。然而，茎皮的乙酸乙酯提取物具有最高的总还原能力，而茎皮的乙醇提取物比所有其他提取物具有更强的自由基清除活性。茎皮的乙酸乙酯提取物比其他提取物表现出更强的羟基自由基清除活性，而叶的水提取物比其他提取物表现出更强的一氧化氮抑制活性。茎皮的乙酸乙酯提取物、根和叶的乙醇提取物的GC-MS分析表明，这些提取物中存在几种芳香族化合物，包括酚类、脂肪酸、氨基酸和三萜类化合物。本研究的数据表明，Cassia singueana的各部位具有抗氧化活性，可作为与氧化应激相关的非传染性慢性病的潜在替代药物。对此进行进一步的实验和临床研究是有必要的。
