Sklenár Zbynek, Scigel Vladimír, Horácková Katerina, Slanar Ondrej
Charles University in Prague, First Faculty of Medicine, Institute of Pharmacology, Albertov 4, 128 00 Prague 2, Czech Republic.
Acta Pol Pharm. 2013 Jul-Aug;70(4):759-62.
Therapy of oral, esophageal and gastrointestinal candidiasis is still a common problem that can be solved by an administration of antimycotics. Major disadvantage of registered commercial antifungal medicinal products is their price, so the health care system and its payers may profit from extemporaneous compounding. An appropriate drug therapy for candidiasis (trush) is nystatin, which is a substance available in the Czech Republic for the magistral preparation relatively recently, since 2010. Making formulas for extemporaneous compounding is quite simple and preparations particularly useful for dentists, pediatricians, otolaryngologists, oncologists and gastroenterologists. The authors formulated composition of viscous oromucosal suspension, oral/oromucosal hydrogel and oromucosal gelatine globule which may be present as compounded products containing nystatin for oromucosal and/or oral administration. The preparation is practically verified and magistral products have been already used in clinical practice.
口腔、食管及胃肠道念珠菌病的治疗仍是一个常见问题，可通过使用抗真菌药物来解决。已注册的商业抗真菌药品的主要缺点是价格昂贵，因此医疗保健系统及其支付方可能会从临时调配药物中获益。治疗念珠菌病（鹅口疮）的一种合适药物是制霉菌素，自2010年起，在捷克共和国可相对较新地获得用于自行配制制剂的该物质。临时调配药物配方相当简单，制剂对牙医、儿科医生、耳鼻喉科医生、肿瘤学家和胃肠病学家特别有用。作者制定了粘性口腔粘膜混悬液、口腔/口腔粘膜水凝胶和口腔粘膜明胶小球的成分，这些成分可以作为含有制霉菌素的复方产品存在，用于口腔粘膜和/或口服给药。该制剂已得到实际验证，自行配制的产品已在临床实践中使用。
