Aly A H, Debbab A, Proksch P
Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universitht DOsseldorf, Germany.
Pharmazie. 2013 Jul;68(7):499-505.
The potential of endophytic fungi as promising sources of bioactive natural products continues to attract broad attention. Endophytic fungi are defined as fungi that live asymptomatically within the tissues of higher plants. This overview will highlight the uniqueness of endophytic fungi as alternative sources of pharmaceutically valuable compounds originally isolated from higher plants, e.g. paclitaxel, camptothecin and podophyllotoxin. In addition, it will shed light on the fungal biosynthesis of plant associated metabolites as well as new approaches developed to improve the production of commercially important plant derived compounds with the involvement of endophytic fungi.
内生真菌作为有前景的生物活性天然产物来源的潜力持续吸引着广泛关注。内生真菌被定义为无症状地生活在高等植物组织内的真菌。本综述将突出内生真菌作为从高等植物中最初分离出的具有药学价值化合物的替代来源的独特性，例如紫杉醇、喜树碱和鬼臼毒素。此外，它将阐明与植物相关代谢产物的真菌生物合成，以及为提高涉及内生真菌的具有商业重要性的植物衍生化合物的产量而开发的新方法。
