Becerra-Jiminez J, Kuschak M, Roeder E, Wiedenfeld H
Pharmazeutisches Institut der Universität, Bonn, Germany.
Pharmazie. 2013 Jul;68(7):636-9.
Pyrrolizidine alkaloids (PAs) can show a hazardous potential for men and animals. They can act as cancerogenic, mutagenic, teratogenic and fetotoxic agents. One pathway of a human intoxication is its occurence as contaminants in food and feed. Here, the contamination of cereals already led to severe and fatal intoxication episodes. Besides this, milk is of special concern as it is the main food for children which show a very high susceptibility for a PA intoxication. Milk can contain PAs in case the milk producing animals have access to contaminated feed. In this context it is of special interest whether the PA content of contaminated silage remains stable during the ensiling procedure or show a more or less high level of decomposition. We could show that ensiling will not lead to PA-free silage.
吡咯里西啶生物碱(PAs)对人和动物可能具有潜在危害。它们可作为致癌、致突变、致畸和胚胎毒性物质。人体中毒的一条途径是其作为食品和饲料中的污染物存在。在此,谷物污染已导致严重和致命的中毒事件。除此之外,牛奶特别值得关注,因为它是儿童的主要食物,而儿童对PA中毒非常敏感。如果产奶动物食用了受污染的饲料,牛奶中就可能含有PAs。在这种情况下,受污染青贮饲料中的PA含量在青贮过程中是保持稳定还是或多或少有较高程度的分解,就特别令人感兴趣。我们可以证明,青贮不会产生不含PA的青贮饲料。