REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal.
Int J Mol Sci. 2018 Jun 5;19(6):1668. doi: 10.3390/ijms19061668.
Pyrrolizidine alkaloids (PA) are widely distributed in plants throughout the world, frequently in species relevant for human consumption. Apart from the toxicity that these molecules can cause in humans and livestock, PA are also known for their wide range of pharmacological properties, which can be exploited in drug discovery programs. In this work we review the current body of knowledge regarding the chemistry, toxicology, pharmacology and food safety of PA.
吡咯里西啶生物碱（PA）广泛存在于世界各地的植物中，经常存在于与人类食用相关的物种中。除了这些分子对人类和牲畜可能造成的毒性之外，PA 还因其广泛的药理特性而闻名，这些特性可在药物发现计划中得到利用。在这项工作中，我们回顾了关于 PA 的化学、毒理学、药理学和食品安全的现有知识体系。
