State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China.
J Am Chem Soc. 2013 Sep 4;135(35):13041-8. doi: 10.1021/ja404985w. Epub 2013 Aug 21.
To integrate photothermal ablation (PTA) with radiotherapy (RT) for improved cancer therapy, we constructed a novel multifunctional core/satellite nanotheranostic (CSNT) by decorating ultrasmall CuS nanoparticles onto the surface of a silica-coated rare earth upconversion nanoparticle. These CSNTs could not only convert near-infrared light into heat for effective thermal ablation but also induce a highly localized radiation dose boost to trigger substantially enhanced radiation damage both in vitro and in vivo. With the synergistic interaction between PTA and the enhanced RT, the tumor could be eradicated without visible recurrence in 120 days. Notably, hematological analysis and histological examination unambiguously revealed their negligible toxicity to the mice within a month. Moreover, the novel CSNTs facilitate excellent upconversion luminescence/magnetic resonance/computer tomography trimodal imagings. This multifunctional nanocomposite is believed to be capable of playing a vital role in future oncotherapy by the synergistic effects between enhanced RT and PTA under the potential trimodal imaging guidance.
为了将光热消融（PTA）与放射治疗（RT）相结合以改善癌症治疗效果，我们通过在二氧化硅包覆的稀土上转换纳米颗粒表面修饰超小的 CuS 纳米粒子，构建了一种新型的多功能核/卫星纳米诊疗剂（CSNT）。这些 CSNTs 不仅可以将近红外光转化为热能以实现有效的热消融，还可以引发高度局部的辐射剂量增强，从而在体外和体内引发显著增强的辐射损伤。通过 PTA 和增强 RT 的协同作用，肿瘤可以在 120 天内被根除，且无明显复发。值得注意的是，血液分析和组织学检查在一个月内明确表明它们对小鼠的毒性可以忽略不计。此外，新型 CSNTs 有利于上转换发光/磁共振/计算机断层扫描的三模态成像。这种多功能纳米复合材料有望在潜在的三模态成像引导下，通过增强 RT 和 PTA 之间的协同作用，在未来的肿瘤治疗中发挥重要作用。
