Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Material Science and Engineering, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100049, China.
J Am Chem Soc. 2021 Oct 6;143(39):16113-16127. doi: 10.1021/jacs.1c06652. Epub 2021 Sep 28.
Integrating multifunctional nanostructures capable of radiotherapy and photothermal ablation is an emerging alternative in killing cancer cells. In this work, we report a novel plasmonic heterostructure formed by decorating AuPt nanoparticles (NPs) onto the surfaces of CuS nanosheets (AuPt@CuS NSs) as a highly effective nanotheranostic toward dual-modal photoacoustic/computed tomography imaging and enhanced synergistic radiophotothermal therapy. These heterostructures can confer higher photothermal conversion efficiency via the local electromagnetic enhancement as well as a greater radiation dose deposition in the form of glutathione depletion and reactive oxygen species generation. As a result, the depth of tissue penetration is improved, and hypoxia of the tumor microenvironment is alleviated. With synergistic enhancement in the efficacy of photothermal ablation and radiotherapy, the tumor can be eliminated without later recurrence. It is believed that these multifunctional heterostructures will play a vital role in future oncotherapy with the enhanced synergistic effects of radiotherapy and photothermal ablation under the guided imaging of a potential dual-modality system.
将具有放射治疗和光热消融功能的多功能纳米结构整合在一起是杀死癌细胞的一种新兴替代方法。在这项工作中，我们报告了一种由金铂纳米颗粒（AuPt NPs）修饰在 CuS 纳米片表面上形成的新型等离子体异质结构（AuPt@CuS NSs），作为一种用于双模态光声/计算机断层扫描成像和增强协同放射光热治疗的高效纳米治疗剂。这些异质结构可以通过局部电磁场增强和谷胱甘肽耗竭和活性氧生成的形式赋予更高的光热转换效率。因此，提高了组织穿透深度，并缓解了肿瘤微环境的缺氧。通过光热消融和放射治疗的协同增效，肿瘤可以被消除而不会复发。相信这些多功能异质结构将在未来的肿瘤治疗中发挥重要作用，通过潜在的双模态系统的引导成像，增强放射治疗和光热消融的协同效应。
