Department of Chemistry and Centre for Catalysis Research and Innovation, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, K1N 6N5, Canada.
Langmuir. 2013 Aug 20;29(33):10521-8. doi: 10.1021/la4019794. Epub 2013 Aug 8.
Hybrid mesoporous silica materials containing gold nanoparticles (AuNPs) have been investigated as potential molecular delivery systems. The photophysical properties of AuNPs, particularly their plasmon band transitions, have been used to control the rate of the release of naproxen from the pores of mesoporous silica matrices. Two different approaches were employed to incorporate AuNPs into the silica network: that is, grafting (using 3-aminopropyltriethoxisilane) and direct absorption. In this research, the anti-inflamatory drug naproxen serves as a test molecule, showing how localized plasmon heating could be used to modify diffusion kinetics within mesoporous materials. Beyond naproxen release, the methodology developed could be employed to release other drugs, sensors, or active molecules, not just in medicine, but in many other fields where nanotechnology is leading to many innovative applications. The hybrid materials developed show a new simple system to efficiently control the release of active cargo from mesoporous silica matrices.
载金纳米粒子（AuNPs）的杂化介孔硅材料已被研究作为潜在的分子输送系统。AuNPs 的光物理性质，特别是它们的等离子体带跃迁，已被用于控制萘普生从介孔硅基质的孔中释放的速率。采用了两种不同的方法将 AuNPs 掺入到硅网络中：即接枝（使用 3-氨基丙基三乙氧基硅烷）和直接吸收。在这项研究中，抗炎药物萘普生作为测试分子，展示了局部等离子体加热如何用于改变介孔材料内的扩散动力学。除了萘普生的释放之外，所开发的方法还可以用于释放其他药物、传感器或活性分子，不仅在医学领域，而且在许多其他领域，纳米技术正在带来许多创新应用。所开发的杂化材料展示了一种从介孔硅基质中高效控制释放活性货物的新简单系统。
