Yamauchi Jun, Sekiguchi Mariko, Shirai Tomomi, Yamada Mami, Ishimi Yoshiko
Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition.
Biosci Biotechnol Biochem. 2013;77(8):1785-7. doi: 10.1271/bbb.130290. Epub 2013 Aug 7.
The production of retinol binding protein 4 (RBP4) is higher in adipose tissue in type 2 diabetes. We have found that proteasome subunit beta type 1 (PSMB1) is a transcriptional activator of Rbp4. In the present study, the putative tyrosine phosphorylation site in PSMB1 was mutated to phenylalanine. The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes.
在2型糖尿病中，视黄醇结合蛋白4（RBP4）在脂肪组织中的产生更高。我们发现蛋白酶体亚基β1型（PSMB1）是Rbp4的转录激活因子。在本研究中，PSMB1中假定的酪氨酸磷酸化位点被突变为苯丙氨酸。PSMB1的突变形式显示出核转位增加，导致脂肪细胞中的转录激活。
