人β-防御素-2 血清水平与早产儿败血症的关系*。

Association of human beta-defensin-2 serum levels and sepsis in preterm neonates*.

机构信息

1Department of Paediatric Infectious Diseases and Immunodeficiency, Hospital Infantil Universitario Virgen del Rocio, Seville, Spain. 2Department of Neonatology and Neonatal Intensive Care Unit, Hospital Infantil Universitario Virgen del Rocio, Seville, Spain. 3Department of Paediatric Haematology, Hospital Infantil Universitario Virgen del Rocio, Seville, Spain. 4Department of Immunology, Hospital Universitario Virgen del Rocio, Seville, Spain. 5Statistics, Methodology and Research Evaluation Unit, Andalusian Public Foundation for Health Research Management in Seville, Seville, Spain.

出版信息

Pediatr Crit Care Med. 2013 Oct;14(8):796-800. doi: 10.1097/PCC.0b013e3182975e0f.

DOI:10.1097/PCC.0b013e3182975e0f

PMID:23925144

Abstract

OBJECTIVES

To determine human beta-defensin-2 levels in term and preterm neonates at birth and to evaluate its impact on sepsis.

DESIGN

Observational study.

SETTING

Single tertiary care hospital.

PATIENTS

Term neonates and preterm neonates were recruited and divided in groups according to important clinical events.

INTERVENTIONS

Cord blood samples were drawn from all newborns immediately after birth. Human beta-defensin-2 levels were determined using enzyme-linked immunosorbent assay technology. All neonates were followed clinically during the first 30 days of life.

MEASUREMENTS AND MAIN RESULTS

Forty-two term and 31 preterm neonates were enrolled. Human beta-defensin-2 levels in term neonates were higher compared with preterm infants (median, 1,882 vs 918 pg/mL; p = 0.003) and correlated with gestational age and birth weight. Of 31 preterm neonates, seven suffered from late-onset sepsis, and this was associated with lower human beta-defensin-2 levels (median, 513 vs 1,411 pg/mL; p = 0.006).

CONCLUSION

Preterm neonates show lower human beta-defensin-2 levels in cord blood compared with term neonates. Low human beta-defensin-2 levels in preterm neonates might be associated with an increased risk of late-onset sepsis.

摘要

目的

测定足月和早产儿出生时人β防御素-2 的水平，并评估其对败血症的影响。

设计

观察性研究。

地点

单家三级保健医院。

患者

足月新生儿和早产儿被招募，并根据重要的临床事件分为组。

干预措施

所有新生儿均在出生后立即采集脐血样本。采用酶联免疫吸附试验技术测定人β防御素-2 水平。所有新生儿在出生后的前 30 天内进行临床随访。

测量和主要结果

共纳入 42 例足月和 31 例早产儿。足月新生儿的人β防御素-2 水平高于早产儿（中位数分别为 1882pg/ml 和 918pg/ml；p=0.003），且与胎龄和出生体重相关。在 31 例早产儿中，有 7 例发生晚发性败血症，且其与较低的人β防御素-2 水平相关（中位数分别为 513pg/ml 和 1411pg/ml；p=0.006）。