Department of Medical Microbiology, Leiden University Medical Center, E1-200, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands,
Eur J Clin Microbiol Infect Dis. 2014 Feb;33(2):197-200. doi: 10.1007/s10096-013-1943-4. Epub 2013 Aug 8.
We report three patients with terminal ileitis and positive fecal cultures with Yersinia pseudotuberculosis. From one patient, a virulence plasmid (pYV)-negative Y. pseudotuberculosis was isolated, which represents the second finding of a pYV-negative isolate associated with human disease. All patients were treated with ciprofloxacin and fully recovered. Since conventional culture methods for yersiniosis are gradually replaced with molecular tests not recognizing Y. pseudotuberculosis, we recommend to include a specific culture medium or to apply a specific polymerase chain reaction (PCR) assay on fecal samples from patients suspected of terminal ileitis.
我们报告了 3 例末端回肠炎和粪便耶尔森菌阳性培养的患者。从 1 例患者中分离出一株毒力质粒（pYV）阴性的假结核耶尔森菌，这是与人类疾病相关的第 2 次 pYV 阴性分离株的发现。所有患者均接受环丙沙星治疗并完全康复。由于用于耶尔森菌病的常规培养方法逐渐被不识别假结核耶尔森菌的分子检测方法所取代，因此我们建议在疑似末端回肠炎的患者粪便样本中加入特定的培养基或应用特定的聚合酶链反应（PCR）检测方法。
