School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, PR China.
Org Biomol Chem. 2013 Sep 28;11(36):5998-6002. doi: 10.1039/c3ob41331d.
A highly efficient palladium-catalyzed carbenoid based N-H bond insertion has been developed. The α-amino esters were obtained in high isolated yields. Moreover, by choosing a suitable chiral auxiliary, stereoselective Pd-catalyzed N-H insertion has been realized. The chiral α-amino esters were obtained in high yields (up to 91%) and with excellent diastereoselectivities (d.r. > 19 : 1).
发展了一种高效的钯催化碳烯型 N-H 键插入反应。高分离收率得到了 α-氨基酯。此外，通过选择合适的手性辅助剂，实现了立体选择性 Pd 催化的 N-H 插入。手性 α-氨基酯以高产率（高达 91%）和优异的非对映选择性（d.r. > 19:1）获得。
