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快速就诊前列腺癌诊所对前列腺癌患者和疾病特征、主要治疗方法和手术工作量的影响。

The effect of a Rapid Access Prostate Cancer Clinic on prostate cancer patient and disease characteristics, primary treatment and surgical workload.

机构信息

St. James's Hospital, Dublin 8, Ireland,

出版信息

Ir J Med Sci. 2014 Jun;183(2):241-7. doi: 10.1007/s11845-013-0997-8. Epub 2013 Aug 8.

Abstract

BACKGROUND

In 2009, Rapid Access Prostate Cancer Clinics (RAPC) were introduced to St. James's Hospital to improve the access and organisation of patients to prostate cancer investigations and treatment.

AIMS

To observe the effects of the RAPC on prostate cancer diagnosis, primary treatment and overall workload.

METHODS

Using a prospectively designed patient database, the records of all prostate cancer patients between 2007 and 2011 were retrieved and analysed. Data were obtained for age, PSA, biopsy Gleason score and primary treatment modality and charted for the observation and comparison of trends.

RESULTS

Seven hundred and eighty-nine patients had a new diagnosis of prostate cancer between 2007 and 2011. The median PSA prior to the RAPC was 9.7-13.1 ng/ml, which decreased to 7.79-9 ng/ml after the RAPC. Prior to the RAPC, 77-81 biopsies were performed annually versus 149-271 in the post-RAPC era. Annual requirements for radical prostatectomy also increased from 12 to 27 in the post-RAPC era. Conversely, an initially increasing percentage of patients for radiotherapy was reversed in the post-RAPC period. An increasing trend for higher grade PCa (Gleason score 4 + 4 and higher) was also reversed.

CONCLUSIONS

The introduction of a RAPC improves the overall pathological characteristics of patients with prostate cancer. However, RAPCs are also associated with a considerable increase in surgical workload. These are important considerations for units considering the incorporation of a similar facility in their institutions.

摘要

背景

2009 年,为改善前列腺癌患者的检查和治疗途径及组织管理,圣詹姆斯医院引入了快速通道前列腺癌诊疗中心(RAPC)。

目的

观察 RAPC 对前列腺癌诊断、初始治疗和总体工作量的影响。

方法

采用前瞻性设计的患者数据库,检索并分析了 2007 年至 2011 年间所有前列腺癌患者的记录。获取了年龄、PSA、前列腺活检 Gleason 评分和初始治疗方式的数据,并进行了图表绘制,以观察和比较趋势。

结果

2007 年至 2011 年间,789 例患者被诊断为前列腺癌。RAPC 引入前,PSA 中位数为 9.7-13.1ng/ml,引入后降至 7.79-9ng/ml。RAPC 引入前,每年进行 77-81 次活检,引入后则为 149-271 次。RAPC 引入后,根治性前列腺切除术的年需求量也从 12 例增加到 27 例。相反,放疗患者的比例最初呈上升趋势,在 RAPC 后则出现逆转。前列腺癌分级较高(Gleason 评分 4+4 及以上)的比例也出现了逆转。

结论

RAPC 的引入改善了前列腺癌患者的整体病理特征。然而,RAPC 也与手术工作量的显著增加有关。对于考虑在机构中引入类似设施的单位,这是重要的考虑因素。

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