National Renewable Energy Laboratory, National Bioenergy Center, Golden, CO, USA.
Proteomics. 2013 Sep;13(17):2544-5. doi: 10.1002/pmic.201300322.
Comparative proteomic analyses have emerged as a powerful tool for the identification of unique biomarkers and mechanisms of pathogenesis. In this issue of Proteomics, Murugaiyan et al. utilize difference gel electrophoresis (DIGE) to examine differential protein expression between nonpathogenic and pathogenic genotypes of Prototheca zopfii, a causative agent in bovine enteritis and mastitis. Their findings provide insights into molecular mechanisms of infection and evolutionary adaptation of pathogenic genotypes, demonstrating the power of comparative proteomic analyses.
比较蛋白质组学分析已成为鉴定独特生物标志物和发病机制的有力工具。在本期《蛋白质组学》中，Murugaiyan 等人利用差异凝胶电泳（DIGE）来检测 Prototheca zopfii 的非致病性和致病性基因型之间的差异蛋白表达，Prototheca zopfii 是引起牛肠炎和乳腺炎的病原体。他们的发现深入了解了感染的分子机制和致病性基因型的进化适应，展示了比较蛋白质组学分析的强大功能。
