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一种单克隆抗体(Mab 67)标记B型滑膜细胞。

A monoclonal antibody (Mab 67) marks type B synoviocytes.

作者信息

Stevens C R, Mapp P I, Revell P A

机构信息

Bone and Joint Research Unit, London Hospital Medical College, UK.

出版信息

Rheumatol Int. 1990;10(3):103-6. doi: 10.1007/BF02274823.

DOI:10.1007/BF02274823
PMID:2392637
Abstract

The functionally important lining cells of the synovium (types A and B synoviocytes) are the subjects of much study but have presented problems with their characterization and microscopical identification, particularly at the light level. Type A (macrophage-like) synoviocytes, however are more easily localized than the type B (fibroblast-like) variety because of the greater availability of antimacrophage antisera. We describe, using light and electron microscopy, a monoclonal antibody which in the synovial intimal layer is specific for type B synoviocytes.

摘要

滑膜中功能重要的衬里细胞(A 型和 B 型滑膜细胞)是众多研究的对象,但在其特征描述和显微镜鉴定方面存在问题,尤其是在光学层面。然而,由于抗巨噬细胞抗血清更容易获得,A型(巨噬细胞样)滑膜细胞比 B 型(成纤维细胞样)滑膜细胞更容易定位。我们使用光学显微镜和电子显微镜描述了一种单克隆抗体,它在滑膜内膜层中对 B 型滑膜细胞具有特异性。

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A monoclonal antibody (Mab 67) marks type B synoviocytes.一种单克隆抗体(Mab 67)标记B型滑膜细胞。
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2
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本文引用的文献

1
Electron microscopy of the human synovial membrane.人体滑膜的电子显微镜检查
J Cell Biol. 1962 Aug;14(2):207-20. doi: 10.1083/jcb.14.2.207.
2
In situ characterization of mononuclear cells in rheumatoid tissues, using monoclonal antibodies. No reduction of T8-positive cells or augmentation in T4-positive cells.使用单克隆抗体对类风湿组织中的单核细胞进行原位表征。T8阳性细胞无减少,T4阳性细胞无增加。
Scand J Immunol. 1982 Oct;16(4):315-9. doi: 10.1111/j.1365-3083.1982.tb00729.x.
3
Identification of three major synovial lining cell populations by monoclonal antibodies directed to Ia antigens and antigens associated with monocytes/macrophages and fibroblasts.
Arthritis Res Ther. 2015 Jan 17;17(1):6. doi: 10.1186/s13075-015-0518-4.
4
Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.NKG2D、DNAM-1、NKp44 和 NKp46 的激活与抑制性 CD94/NKG2A 受体之间的平衡决定了自然杀伤细胞对类风湿关节炎滑膜成纤维细胞的脱颗粒作用。
Immunology. 2014 Aug;142(4):581-93. doi: 10.1111/imm.12271.
5
Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts.dsRNA 传感器 TLR3、MDA5 和 RIG-I 的触发可诱导滑膜成纤维细胞中 CD55 的表达。
PLoS One. 2012;7(5):e35606. doi: 10.1371/journal.pone.0035606. Epub 2012 May 10.
6
The normal synovium.正常滑膜。
Open Rheumatol J. 2011;5:100-6. doi: 10.2174/1874312901105010100. Epub 2011 Dec 30.
7
Ionic currents in intimal cultured synoviocytes from the rabbit.兔关节滑膜细胞内膜离子流。
Am J Physiol Cell Physiol. 2010 Nov;299(5):C1180-94. doi: 10.1152/ajpcell.00028.2010. Epub 2010 Aug 18.
8
The antimicrobial peptide HBD-2 and the Toll-like receptors-2 and -4 are induced in synovial membranes in case of septic arthritis.在脓毒性关节炎病例中,滑膜中会诱导产生抗菌肽HBD-2以及Toll样受体-2和-4。
Virchows Arch. 2009 Jun;454(6):685-94. doi: 10.1007/s00428-009-0780-4. Epub 2009 May 3.
9
The combined role of wear particles, macrophages and lymphocytes in the loosening of total joint prostheses.磨损颗粒、巨噬细胞和淋巴细胞在全关节假体松动中的联合作用。
J R Soc Interface. 2008 Nov 6;5(28):1263-78. doi: 10.1098/rsif.2008.0142.
10
Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro.钙黏蛋白-11诱导类风湿性关节炎成纤维样滑膜细胞在体外形成衬里层。
Am J Pathol. 2006 May;168(5):1486-99. doi: 10.2353/ajpath.2006.050999.
通过针对Ia抗原以及与单核细胞/巨噬细胞和成纤维细胞相关的抗原的单克隆抗体鉴定出三种主要的滑膜衬里细胞群。
Scand J Immunol. 1983 Jan;17(1):69-82. doi: 10.1111/j.1365-3083.1983.tb00767.x.
4
Fibronectin in the synovium of chronic inflammatory joint disease.慢性炎症性关节疾病滑膜中的纤连蛋白
Rheumatol Int. 1984;4(3):129-33. doi: 10.1007/BF00541182.
5
Fibronectin production by synovial intimal cells.滑膜内膜细胞产生纤连蛋白。
Rheumatol Int. 1985;5(5):229-37. doi: 10.1007/BF00541341.
6
Features of synovial membrane identified with monoclonal antibodies.用单克隆抗体鉴定的滑膜特征。
Clin Exp Immunol. 1985 Mar;59(3):529-38.
7
Absorption of intraarticularly injected horseradish peroxidase in synoviocytes of rat synovial membrane: an ultrastructural-cytochemical study.
J Ultrastruct Res. 1985 Jul-Aug;92(1-2):86-100. doi: 10.1016/0889-1605(85)90131-4.
8
Ultrastructural characterisation of macrophages (type A cells) in the synovial lining.滑膜衬里中巨噬细胞(A型细胞)的超微结构特征
Rheumatol Int. 1988;8(4):171-6. doi: 10.1007/BF00270456.
9
Mononuclear phagocytes of normal and rheumatoid synovial membrane identified by monoclonal antibodies.用单克隆抗体鉴定正常和类风湿性滑膜的单核吞噬细胞。
Immunology. 1985 Dec;56(4):673-81.
10
The identification of glycoproteins associated with elastic-tissue microfibrils.与弹性组织微原纤维相关的糖蛋白的鉴定。
Biochem J. 1978 Mar 15;170(3):715-8. doi: 10.1042/bj1700715.