Kohno Hitoshi, Tanaka Toshiaki, Fujieda Kenji, Chihara Kazuo, Seino Yoshiki, Irie Minoru, Takano Kazue
Department of Endocrinology and Metabolism, Fukuoka Children's Hospital, Fukuoka, Japan.
Clin Pediatr Endocrinol. 2012 Apr;21(2):15-20. doi: 10.1297/cpe.21.15. Epub 2012 Mar 24.
Growth hormone (GH) affects body composition and atherogenic risk factors. Severe hyperlipidemia may develop in GH-deficient adults as a consequence of continuous GH deficiency. We investigated changes in lipid profiles in 158 Japanese children (103 boys and 55 girls) with GH deficiency who had been enrolled in the Pfizer International Growth Database Japan during 3 yr of GH replacement therapy to evaluate whether GH treatment has beneficial effects on atherogenic risk factors. Total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC) and atherogenic index were evaluated before treatment and then once a year during treatment. The mean baseline TC was within the normal range in both boys and girls. Seventeen (16.5%) of the 103 boys and 18 (32.7%) of the 55 girls, however, had a TC level over 200 mg/dl before treatment. The mean TC level showed a significant decrease in girls. In a separate analysis, patients of both sexes with a TC level > 200 mg/dl showed significantly decreased TC. LDLC decreased significantly only in girls, while HDLC showed no change in either sex. The atherogenic index decreased significantly in girls. GH replacement therapy in children with GH deficiency had beneficial effects on lipid metabolism and atherogenic risk in both sexes. Early GH treatment would produce lipid metabolism benefits in these patients.
生长激素（GH）会影响身体成分和动脉粥样硬化风险因素。由于持续的生长激素缺乏，生长激素缺乏的成年人可能会出现严重的高脂血症。我们调查了158名日本生长激素缺乏儿童（103名男孩和55名女孩）在接受3年生长激素替代治疗期间血脂谱的变化，这些儿童已被纳入辉瑞国际生长数据库日本分库，以评估生长激素治疗对动脉粥样硬化风险因素是否有有益影响。在治疗前以及治疗期间每年评估一次总胆固醇（TC）、高密度脂蛋白胆固醇（HDLC）、低密度脂蛋白胆固醇（LDLC）和动脉粥样硬化指数。男孩和女孩的平均基线总胆固醇均在正常范围内。然而，103名男孩中有17名（16.5%）和55名女孩中有18名（32.7%）在治疗前总胆固醇水平超过200mg/dl。女孩的平均总胆固醇水平显著下降。在一项单独分析中，总胆固醇水平>200mg/dl的男女患者总胆固醇均显著下降。仅女孩的低密度脂蛋白胆固醇显著下降，而高密度脂蛋白胆固醇在男女中均无变化。女孩的动脉粥样硬化指数显著下降。生长激素缺乏儿童的生长激素替代治疗对男女的脂质代谢和动脉粥样硬化风险均有有益影响。早期生长激素治疗将给这些患者带来脂质代谢方面的益处。
