转诊至伊朗输血组织研究中心的不育男性的染色体异常情况。
Chromosomal abnormalities in infertile men referred to iran blood transfusion organization research center.
作者信息
Frouzandeh Mahjoubi, Saeideh Soleimani, Sanaz Mantegy
机构信息
Department of Cytogenetics, Iran Blood Transfusion Organization Research Center (IBTO), Tehran, Iran ; National Research Institute for Genetic Engineering and Biotechnology, Tehran, Iran.
出版信息
J Reprod Infertil. 2010 Oct;11(3):175-8.
INTRODUCTION
The prevalence of somatic chromosomal abnormalities in infertile male individuals has been reported to vary in different literatures. The aim of this study was to investigate the frequency of chromosomal aberrations among infertile men referred to the Cytogenetic Laboratory of Iran Blood Transfusion Organization Research Centre (IBTO).
MATERIALS AND METHODS
Chromosomal analysis was performed on phytohemag-glutinin (PHA)-stimulated peripheral lymphocyte cultures of 1052 infertile men using standard cytogenetic methods. The study took place during 1997 to 2007.
RESULTS
Total chromosome alterations were revealed in 161 (15.30%) infertile men. The most prevalent chromosomal abnormality in the infertile men was 47, XXY, that was seen in 94 (58.38%) men while one of them had a mosaic karyotype: mos 47, XX[54]/47,XXY[18]/46,XY[9]. In 37 (22.98%) cases, structural aberrations were detected. There were 30 (18.63%) cases of sex reversal.
CONCLUSION
Cytogenetic studies of these patients showed increased chromosomal abnormalities in infertile men in comparison with that of the normal population, justifying the need for cytogenetic analysis of men with idiopathic infertility.
引言
不同文献报道不育男性个体中体细胞染色体异常的发生率有所不同。本研究旨在调查转诊至伊朗输血组织研究中心（IBTO）细胞遗传学实验室的不育男性中染色体畸变的频率。
材料与方法
采用标准细胞遗传学方法，对1052名不育男性经植物血凝素（PHA）刺激的外周淋巴细胞培养物进行染色体分析。研究于1997年至2007年期间进行。
结果
161名（15.30%）不育男性存在染色体改变。不育男性中最常见的染色体异常是47, XXY，见于94名（58.38%）男性，其中1名具有嵌合核型：mos 47, XX[54]/47,XXY[18]/46,XY[9]。在37例（22.98%）中检测到结构畸变。有30例（18.63%）性反转。
结论
对这些患者的细胞遗传学研究表明，与正常人群相比，不育男性的染色体异常增加，这证明对特发性不育男性进行细胞遗传学分析是必要的。
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